ArticleProceedings of the National Academy of Sciences of the United States of America2000
Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 126 citations in OpenAlex.
- An Array SPRi Biosensor for the Determination on PARP-1 in Blood Plasma.Biomedicines · 2023Article
- PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols.International journal of molecular sciences · 2021Review
- Poly(ADP-ribose) polymerase inhibition: past, present and future.Nature reviews. Drug discovery · 2020Review
- PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs.International journal of molecular sciences · 2017Review
- Trial watch - inhibiting PARP enzymes for anticancer therapy.Molecular & cellular oncology · 2016Review
- Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation.PloS one · 2015Article
- Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.Molecular aspects of medicine · 2013Review
- Functional Aspects of PARP1 in DNA Repair and Transcription.Biomolecules · 2012Article
- Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation.Oxidative medicine and cellular longevity · 2012Review
- PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration.Cell communication and signaling : CCS · 2010Article
- PARP inhibition: PARP1 and beyond.Nature reviews. Cancer · 2010Review
- Enhanced binding of poly(ADP-ribose)polymerase-1 and Ku80/70 to the ITGA2 promoter via an extended cytosine-adenosine repeat.PloS one · 2010Article
- Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells.The Journal of biological chemistry · 2009Article
- PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.The Journal of biological chemistry · 2009Article
- Parp and cell death or protection in rat primary astroglial cell cultures under LPS/IFNgamma induced proinflammatory conditions.Neurochemical research · 2008Article
- Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation.Current opinion in cell biology · 2008Review
- Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation.BMC genomics · 2008Article
- Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells.BMC genomics · 2007Article
- Nitric oxide and peroxynitrite in health and disease.Physiological reviews · 2007Review
- Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression.BMC molecular biology · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Poly(ADP-ribose) polymerase (PARP) is implicated in the maintenance of genomic integrity, given that inhibition or depletion of this enzyme increases genomic instability in cells exposed to genotoxic agents. We previously showed that immortalized fibroblasts derived from PARP(-/-) mice exhibit an unstable tetraploid population, and partial chromosomal gains and losses in PARP(-/-) mice and immortalized fibroblasts are accompanied by changes in the expression of p53, Rb, and c-Jun, as well as other proteins. A tetraploid population has also now been detected in primary fibroblasts derived from PARP(-/-) mice. Oligonucleotide microarray analysis was applied to characterize more comprehensively the differences in gene expression between asynchronously dividing primary fibroblasts derived from PARP(-/-) mice and their wild-type littermates. Of the 11,000 genes monitored, 91 differentially expressed genes were identified. The loss of PARP results in down-regulation of the expression of several genes involved in regulation of cell cycle progression or mitosis, DNA replication, or chromosomal processing or assembly. PARP deficiency also up-regulates genes that encode extracellular matrix or cytoskeletal proteins that are implicated in cancer initiation or progression or in normal or premature aging. These results provide insight into the mechanism by which PARP deficiency impairs mitotic function, thereby resulting in the genomic alterations and chromosomal abnormalities as well as in altered expression of genes that may contribute to genomic instability, cancer, and aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.