ArticleJournal of clinical microbiology2000
Molecular epidemiology of Entamoeba spp.: evidence of a bottleneck (Demographic sweep) and transcontinental spread of diploid parasites.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 97 citations in OpenAlex.
- Concomitant Borreliosis and Invasive Amoebiasis: A Rare Case with Suspected Sexual Acquisition.Infectious disease reports · 2026Article
- Prevalence and genotypic diversity of Entamoeba species in inhabitants in Kathmandu, Nepal.Parasitology research · 2018Article
- Article
- TheCurrent tropical medicine reports · 2016Article
- Species-Specific Immunodetection of an Entamoeba histolytica Cyst Wall Protein.PLoS neglected tropical diseases · 2016Article
- Evolutionary genomics and population structure of Entamoeba histolytica.Computational and structural biotechnology journal · 2014Review
- Correlation between genotypes of tRNA-linked short tandem repeats in Entamoeba nuttalli isolates and the geographical distribution of host rhesus macaques.Parasitology research · 2014Article
- Prevalence and genetic diversity of Entamoeba species infecting macaques in southwest China.Parasitology research · 2013Article
- Unique short tandem repeat nucleotide sequences in Entamoeba histolytica isolates from China.Parasitology research · 2012Article
- A Multilocus Sequence Typing System (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence.BMC microbiology · 2012Article
- Evidence for a link between locus R-R sequence type and outcome of infection with Entamoeba histolytica.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2012Article
- Genomic diversity of the human intestinal parasite Entamoeba histolytica.Genome biology · 2012Article
- High prevalence of Entamoeba infections in captive long-tailed macaques in China.Parasitology research · 2011Article
- Different structure and mRNA expression of Entamoeba invadens chitinases in the encystation and excystation.Parasitology research · 2011Article
- A simple fibril and lectin model for cyst walls of Entamoeba and perhaps Giardia.Trends in parasitology · 2011Article
- Comparison of serine-rich protein genes of Entamoeba histolytica isolates obtained from institutions for the mentally retarded in Kanagawa and Shizuoka Prefectures, Japan.Parasitology research · 2010Article
- The Jacob2 lectin of the Entamoeba histolytica cyst wall binds chitin and is polymorphic.PLoS neglected tropical diseases · 2010Article
- Human amebiasis: breaking the paradigm?International journal of environmental research and public health · 2010Article
- DNA characterization of simian Entamoeba histolytica-like strains to differentiate them from Entamoeba histolytica.Parasitology research · 2009Article
- Evidence for a "wattle and daub" model of the cyst wall of entamoeba.PLoS pathogens · 2009Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Entamoeba histolytica causes amebic colitis and liver abscess in developing countries such as Mexico and India. Entamoeba dispar is morphologically identical but is not associated with disease. Here we determined the ploidy of E. histolytica and developed PCR-based methods for distinguishing field isolates of E. histolytica or E. dispar. Fluorescence in situ hybridization showed that E. histolytica trophozoites are diploid for five "single-copy" probes tested. Intergenic sequences between superoxide dismutase and actin 3 genes of clinical isolates of E. histolytica from the New and Old Worlds were identical, as were those of E. dispar. These results suggest a bottleneck or demographic sweep in entamoebae which infect humans. In contrast, E. histolytica and E. dispar genes encoding repeat antigens on the surface of trophozoites (Ser-rich protein) or encysting parasites (chitinase) were highly polymorphic. chitinase alleles suggested that the early axenized strains of E. histolytica, HM-1 from Mexico City, Mexico, and NIH-200 from Calcutta, India, are still present and that similar E. dispar parasites can be identified in both the New and Old Worlds. Ser-rich protein alleles, which suggested the presence of the HM-1 strain in Mexico City, included some E. histolytica genes that predicted Ser-rich proteins with very few repeats. These results, which suggest diversifying selection at chitinase and Ser-rich protein loci, demonstrate the usefulness of these alleles for distinguishing clinical isolates of E. histolytica and E. dispar.
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