ArticleJournal of clinical microbiology2000
Class 1 integron-borne, multiple-antibiotic resistance encoded by a 150-kilobase conjugative plasmid in epidemic vibrio cholerae O1 strains isolated in Guinea-Bissau.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 82 citations in OpenAlex.
- Antibiotic-Resistant Vibrio cholerae O1 and Its SXT Elements Associated with Two Cholera Epidemics in Kenya in 2007 to 2010 and 2015 to 2016.Microbiology spectrum · 2023Article
- Resistance ofFrontiers in pharmacology · 2023Review
- Antibiotic Resistance Conferred by Class 1 Integron in Vibrio Cholerae Strains: A Meta-analysis.The East African health research journal · 2022Review
- Geographical distribution and antibiotics susceptibility patterns of toxigenic Vibrio cholerae isolates from Kisumu County, Kenya.African journal of primary health care & family medicine · 2020Article
- Virulence, Resistance, and Genomic Fingerprint Traits ofMicrobial drug resistance (Larchmont, N.Y.) · 2020Article
- Quality Assessment of Three Types of Drinking Water Sources in Guinea-Bissau.International journal of environmental research and public health · 2020Article
- Antimicrobial resistance ofAfrican journal of laboratory medicine · 2018Review
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- Article
- Role of integrons, plasmids and SXT elements in multidrug resistance of Vibrio cholerae and Providencia vermicola obtained from a clinical isolate of diarrhea.Frontiers in microbiology · 2015Article
- Development of pVCR94ΔX from Vibrio cholerae, a prototype for studying multidrug resistant IncA/C conjugative plasmids.Frontiers in microbiology · 2014Article
- Molecular characterization of the circulating strains of Vibrio cholerae during 2010 cholera outbreak in Nigeria.Journal of health, population, and nutrition · 2013Article
- Simultaneous Detection of Integrase and Antibiotic Resistance Genes within SXT Constin in Vibrio cholerae O1 El Tor Strains Isolated from Iran Using Multiplex-PCR.Iranian journal of basic medical sciences · 2012Article
- Multiple antibiotic resistance of Vibrio cholerae serogroup O139 in China from 1993 to 2009.PloS one · 2012Article
- Drug-resistance mechanisms in Vibrio cholerae O1 outbreak strain, Haiti, 2010.Emerging infectious diseases · 2011Article
- Molecular characterization of Vibrio cholerae outbreak strains with altered El Tor biotype from southern India.World journal of microbiology & biotechnology · 2010Article
- Identification, cloning, and functional characterization of EmrD-3, a putative multidrug efflux pump of the major facilitator superfamily from Vibrio cholerae O395.Archives of microbiology · 2009Article
- Vibrio cholerae O139 multiple-drug resistance mediated by Yersinia pestis pIP1202-like conjugative plasmids.Antimicrobial agents and chemotherapy · 2008Article
- Vibrio cholerae O1 from Accra, Ghana carrying a class 2 integron and the SXT element.The Journal of antimicrobial chemotherapy · 2008Article
- Growing problem of multidrug-resistant enteric pathogens in Africa.Emerging infectious diseases · 2007Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the 1996-1997 cholera epidemic in Guinea-Bissau, surveillance for antimicrobial resistance showed the emergence of a multidrug-resistant strain of Vibrio cholerae O1 during the course of the epidemic. The strain was resistant to ampicillin, erythromycin, tetracycline, furazolidone, aminoglycosides, trimethoprim, and sulfamethoxazole. Concomitant with the emergence of this strain, we observed a resurgence in the number of registered cholera cases as well as an increase in the case fatality rate from 1.0% before the emergence of the multiple-drug-resistant strain to 5.3% after the emergence of the strain. Our study shows that the strain contained a 150-kb conjugative multiple-antibiotic resistance plasmid with class 1 integron-borne gene cassettes encoding resistance to trimethoprim (dhfrXII) and aminoglycosides [ant(3")-1a]). The finding of transferable resistance to almost all of the antibiotics commonly used to treat cholera is of great public health concern. Studies should be carried out to determine to what extent the strain or its resistance genes have been spread to other areas where cholera is endemic.
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