ArticleJournal of clinical microbiology2000
Helicobacter pylori: clonal population structure and restricted transmission within families revealed by molecular typing.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- Article
- [Research progress on genotyping ofZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
- Multiple infection and microdiversity among Helicobacter pylori isolates in a single host in India.PloS one · 2012Article
- Genetic relationships among Italian and Mexican maize-rhizosphere Burkholderia cepacia complex (BCC) populations belonging to Burkholderia cenocepacia IIIB and BCC6 group.BMC microbiology · 2011Article
- Intrafamilial Genotyping of Helicobacter pylori from Faecal DNA.Gastroenterology research and practice · 2011Article
- Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Horizontal versus familial transmission of Helicobacter pylori.PLoS pathogens · 2008Article
- Using macro-arrays to study routes of infection of Helicobacter pylori in three families.PloS one · 2008Article
- Genomic methylation: a tool for typing Helicobacter pylori isolates.Applied and environmental microbiology · 2007Article
- Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection.Journal of bacteriology · 2007Article
- Slow genetic divergence of Helicobacter pylori strains during long-term colonization.Infection and immunity · 2005Article
- Does hospital work constitute a risk factor for Helicobacter pylori infection?The Journal of hospital infection · 2005Article
- Direct transmission of H. pylori from challenged to nonchallenged mice in a single cage.Digestive diseases and sciences · 2005Article
- Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method.Journal of clinical microbiology · 2005Article
- Helicobacter pylori and gastroduodenal pathology: new threats of the old friend.Annals of clinical microbiology and antimicrobials · 2005Review
- Sequence organization and insertion specificity of the novel chimeric ISHp609 transposable element of Helicobacter pylori.Journal of bacteriology · 2004Article
- Genetic and transmission analysis of Helicobacter pylori strains within a family.Emerging infectious diseases · 2004Article
- Helicobacter acinonychis: genetic and rodent infection studies of a Helicobacter pylori-like gastric pathogen of cheetahs and other big cats.Journal of bacteriology · 2004Article
- Concordance of Helicobacter pylori strains within families.Journal of clinical microbiology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infects up to 50% of the human population worldwide. The infection occurs predominantly in childhood and persists for decades or a lifetime. H. pylori is believed to be transmitted from person to person. However, tremendous genetic diversity has been reported for these bacteria. In order to gain insight into the epidemiological basis of this phenomenon, we performed molecular typing of H. pylori isolates from different families. Fifty-nine H. pylori isolates from 27 members of nine families were characterized by using restriction fragment length polymorphism analysis of five PCR-amplified genes, by pulsed-field gel electrophoresis (PFGE) of chromosomal DNA, and by vacA and cagA genotyping. The 16S rRNA gene exhibited little allelic variation, as expected for a unique bacterial species. In contrast, the vacA, flaA, ureAB, and lspA-glmM genes were highly polymorphic, with a mean genetic diversity of 0.83, which exceeds the levels recorded for all other bacterial species. In conjunction with PFGE, 59 H. pylori isolates could be differentiated into 21 clonal types. Each individual harbored only one clone, occasionally with a clonal variant. Identical strains were always found either between siblings or between a mother and her children. Statistical analysis revealed clonality of population structure in all isolates. The results of this study suggest the possible coexistence of a large array of clonal lineages that are evolving in each individual in isolation from one another. Transmission appears to occur primarily from mother to child and perhaps between siblings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.