ArticleJournal of clinical microbiology2000
Elevated phenotypic switching and drug resistance of Candida albicans from human immunodeficiency virus-positive individuals prior to first thrush episode.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 86 citations in OpenAlex.
- Phenotypes characterization and ABC genotypes distribution of clinical Candida albicans isolates.Journal of clinical laboratory analysis · 2023Article
- HYPHAEdelity: a quantitative image analysis tool for assessing peripheral whole colony filamentation.FEMS yeast research · 2022Article
- Review
- Genotyping, antifungal susceptibility, enzymatic activity, and phenotypic variation in Candida albicans from esophageal candidiasis.Journal of clinical laboratory analysis · 2021Article
- Identification of Fungi Isolated from Oral Cavity of Patients with HIV Using MALDI-TOF MS.Journal of clinical medicine · 2021Article
- Chromatin Structure and Drug Resistance inJournal of fungi (Basel, Switzerland) · 2020Review
- Integrated Analysis of Clinical and Microbiome Risk Factors Associated with the Development of Oral Candidiasis during Cancer Chemotherapy.Journal of fungi (Basel, Switzerland) · 2019Article
- Phenotypic switching of Candida guilliermondii is associated with pseudohyphae formation and antifungal resistance.Mycopathologia · 2015Article
- Virulence of Candida albicans isolated from HIV infected and non infected individuals.SpringerPlus · 2015Article
- Variability of phenotypic traits in Cryptococcus varieties and species and the resulting implications for pathogenesis.Future microbiology · 2010Review
- Candida infections of the genitourinary tract.Clinical microbiology reviews · 2010Review
- Antigenic and phenotypic variations in fungi.Cellular microbiology · 2009Review
- Phenotypic Switching in Fungi.Current fungal infection reports · 2008Article
- Fluconazole resistant opportunistic oro-pharyngeal Candida and non-Candida yeast-like isolates from HIV infected patients attending ARV clinics in Lagos, Nigeria.African health sciences · 2008Article
- Phenotypic switching and its implications for the pathogenesis of Cryptococcus neoformans.FEMS yeast research · 2006Review
- Phenotypic switching in Candida lusitaniae on copper sulfate indicator agar: association with amphotericin B resistance and filamentation.Journal of clinical microbiology · 2006Article
- Phenotypic switching in Cryptococcus neoformans.Microbiology (Reading, England) · 2006Review
- Characterization of switch phenotypes in Candida albicans biofilms.Mycopathologia · 2005Article
- Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection.Infection and immunity · 2005Article
- Role of phagocytosis in the virulence of Cryptococcus neoformans.Eukaryotic cell · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Strains of Candida albicans obtained from human immunodeficiency virus (HIV)-positive individuals prior to their first episode of oral thrush were already in a high-frequency mode of switching and were far more resistant to a number of antifungal drugs than commensal isolates from healthy individuals. Switching in these isolates also had profound effects both on susceptibility to antifungal drugs and on the levels of secreted proteinase activity. These results suggest that commensal strains colonizing HIV-positive individuals either undergo phenotypic alterations or are replaced prior to the first episode of oral thrush. They also support the suggestion that high-frequency phenotypic switching functions as a higher-order virulence trait, spontaneously generating in colonizing populations variants with alterations in a variety of specific virulence traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.