ArticleGenetics2000
Hierarchical patterns of transgene expression indicate involvement of developmental mechanisms in the regulation of the maize P1-rr promoter.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Uniform Expression and Relatively Small Position Effects Characterize Sister Transformants in Maize and Soybean.Frontiers in plant science · 2019Article
- Ending event-based regulation of GMO crops.Nature biotechnology · 2016Article
- Analysis of the P1 promoter in response to UV-B radiation in allelic variants of high-altitude maize.BMC plant biology · 2012Article
- Maize Unstable factor for orange1 is required for maintaining silencing associated with paramutation at the pericarp color1 and booster1 loci.PLoS genetics · 2012Article
- Divergence of gene regulation through chromosomal rearrangements.BMC genomics · 2010Article
- Transcriptionally silenced transgenes in maize are activated by three mutations defective in paramutation.Genetics · 2006Article
- Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis.Plant molecular biology · 2006Article
- A maize QTL for silk maysin levels contains duplicated Myb-homologous genes which jointly regulate flavone biosynthesis.Plant molecular biology · 2003Article
- Transgene-induced silencing identifies sequences involved in the establishment of paramutation of the maize p1 gene.The Plant cell · 2001Article
- A segmental gene duplication generated differentially expressed myb-homologous genes in maize.The Plant cell · 2000Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maize P1-rr gene encodes a Myb-homologous transcription factor that regulates the synthesis of red flavonoid pigments. Maize plants transformed with segments of the P1-rr promoter driving a GUS reporter gene exhibit significant variation in transgene expression, both between independent transformation events and among sibling plants derived from a single event. Interestingly, variability in spatial expression is not random; rather, transgene activity occurs predominantly in five patterns that fit a hierarchy: expression is most common in kernel pericarp, with sequential addition of expression in cob glumes, husk, silk, and tassel. The hierarchical expression pattern of P-rr::GUS transgenes suggests a possible model for developmental regulation of the P1-rr gene. Our results demonstrate that variability in transgene expression, a common occurrence in transgenic plant studies, can be informative if adequately analyzed to uncover underlying patterns of gene expression.
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Registered trials
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