ArticleGenetics2000
Archaic lineages in the history of modern humans.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes.Genes · 2018Review
- Article
- Human Dispersal Out of Africa: A Lasting Debate.Evolutionary bioinformatics online · 2015Review
- Genetic variation and adaptation in Africa: implications for human evolution and disease.Cold Spring Harbor perspectives in biology · 2014Review
- Article
- Genomic data reveal a complex making of humans.PLoS genetics · 2012Review
- The date of interbreeding between Neandertals and modern humans.PLoS genetics · 2012Article
- Female-to-male breeding ratio in modern humans-an analysis based on historical recombinations.American journal of human genetics · 2010Article
- A population genetics study of the familial Mediterranean fever gene: evidence of balancing selection under an overdominance regime.Genes and immunity · 2009Article
- Article
- Tracing genetic history of modern humans using X-chromosome lineages.Human genetics · 2007Article
- The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region.American journal of human genetics · 2005Article
- Genetic variability in a genomic region with long-range linkage disequilibrium reveals traces of a bottleneck in the history of the European population.Human genetics · 2005Article
- Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.American journal of human genetics · 2003Article
- DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection.American journal of human genetics · 2002Article
- Major genomic mitochondrial lineages delineate early human expansions.BMC genetics · 2001Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important question in the ongoing debate on the origin of Homo sapiens is whether modern human populations issued from a single lineage or whether several, independently evolving lineages contributed to their genetic makeup. We analyzed haplotypes composed of 35 polymorphisms from a segment of the dystrophin gene. We find that the bulk of a worldwide sample of 868 chromosomes represents haplotypes shared by different continental groups. The remaining chromosomes carry haplotypes specific for the continents or for local populations. The haplotypes specific for non-Africans can be derived from the most frequent ones through simple recombination or a mutation. In contrast, chromosomes specific for sub-Saharan Africans represent a distinct group, as shown by principal component analysis, maximum likelihood tree, structural comparison, and summary statistics. We propose that African chromosomes descend from at least two lineages that have been evolving separately for a period of time. One of them underwent range expansion colonizing different continents, including Africa, where it mixed with another, local lineage represented today by a large fraction of African-specific haplotypes. Genetic admixture involving archaic lineages appears therefore to have occurred within Africa rather than outside this continent, explaining greater diversity of sub-Saharan populations observed in a variety of genetic systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.