ArticleGenetics2000
Evolution of odorant receptors expressed in mammalian testes.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Influence of MHC on genetic diversity and testicular expression of linked olfactory receptor genes.BMC genomics · 2025Article
- Review
- Genome-Wide Identification and Characterization of Olfactory Receptor Genes in Chinese Perch,Genes · 2019Article
- Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease.Frontiers in aging neuroscience · 2016Review
- Article
- Olfactory receptors in non-chemosensory tissues.BMB reports · 2012Review
- Development of a porcine (Sus scofa) embryo-specific microarray: array annotation and validation.BMC genomics · 2012Article
- Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm.The Journal of biological chemistry · 2011Article
- Conservation of indole responsive odorant receptors in mosquitoes reveals an ancient olfactory trait.Chemical senses · 2011Article
- Self/nonself perception, reproduction and the extended MHC.Self/nonself · 2010Article
- Candidate chemoreceptor subfamilies differentially expressed in the chemosensory organs of the mollusc Aplysia.BMC biology · 2009Article
- A signature of evolutionary constraint on a subset of ectopically expressed olfactory receptor genes.Molecular biology and evolution · 2009Article
- Mammalian olfactory receptors.Frontiers in cellular neuroscience · 2009Article
- Selective pressures on Drosophila chemosensory receptor genes.Journal of molecular evolution · 2007Article
- Evolution and comparative genomics of odorant- and pheromone-associated genes in rodents.Genome research · 2004Article
- The human olfactory receptor repertoire.Genome biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About 10% of mammalian odorant receptors are transcribed in testes, and odorant-receptor proteins have been detected on mature spermatozoa. Testis-expressed odorant receptors (TORs) are hypothesized to play roles in sperm chemotaxis, but they might also be ordinary nasal odorant receptors (NORs) that are expressed gratuitously in testes. Under the sperm-chemotaxis hypothesis, TORs should be subject to intense sexual selection and therefore should show higher rates of amino acid substitution than NORs, but under the gratuitous-expression hypothesis, TORs are misidentified NORs and therefore should evolve like other NORs. To test these predictions, we estimated synonymous and nonsynonymous divergences of orthologous NOR and TOR coding sequences from rat and mouse. Contrary to both hypotheses, TORs are on average more highly conserved than NORs, especially in certain domains of the OR protein. This pattern suggests that some TORs might perform internal nonolfactory functions in testes; for example, they might participate in the regulation of sperm development. However, the pattern is also consistent with a modified gratuitous-expression model in which NORs with specialized ligand specificities are both more highly conserved than typical NORs and more likely to be expressed in testes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.