ArticleGenetics2000
The Drosophila mus101 gene, which links DNA repair, replication and condensation of heterochromatin in mitosis, encodes a protein with seven BRCA1 C-terminus domains.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 68 citations in OpenAlex.
- Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during Mitosis.Journal of virology · 2022Article
- Article
- Characterisation of unessential genes required for survival under conditions of DNA stress.Journal, genetic engineering & biotechnology · 2020Article
- Rapid DNA Synthesis During EarlyGenetics · 2017Article
- DNA Replication Control DuringGenetics · 2017Review
- Review
- MDC1 collaborates with TopBP1 in DNA replication checkpoint control.The Journal of cell biology · 2011Article
- A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint.Science signaling · 2011Article
- BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.Molecular cell · 2010Article
- A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.Genes & development · 2010Article
- Article
- Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication.Molecular biology of the cell · 2009Article
- Conservation of epigenetic regulation, ORC binding and developmental timing of DNA replication origins in the genus Drosophila.Genetics · 2007Article
- The role of CDK in the initiation step of DNA replication in eukaryotes.Cell division · 2007Article
- Multiple-pathway analysis of double-strand break repair mutations in Drosophila.PLoS genetics · 2007Article
- TopBP1 regulates human papillomavirus type 16 E2 interaction with chromatin.Journal of virology · 2007Article
- TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains.The Biochemical journal · 2006Article
- A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11.The EMBO journal · 2006Article
- Human TopBP1 ensures genome integrity during normal S phase.Molecular and cellular biology · 2005Article
- DNA replication and progression through S phase.Oncogene · 2005Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mutagen-sensitive-101 (mus101) gene of Drosophila melanogaster was first identified 25 years ago through mutations conferring larval hypersensitivity to DNA-damaging agents. Other alleles of mus101 causing different phenotypes were later isolated: a female sterile allele results in a defect in a tissue-specific form of DNA synthesis (chorion gene amplification) and lethal alleles cause mitotic chromosome instability that can be observed genetically and cytologically. The latter phenotype presents as a striking failure of mitotic chromosomes of larval neuroblasts to undergo condensation of pericentric heterochromatic regions, as we show for a newly described mutant carrying lethal allele mus101(lcd). To gain further insight into the function of the Mus101 protein we have molecularly cloned the gene using a positional cloning strategy. We report here that mus101 encodes a member of the BRCT (BRCA1 C terminus) domain superfamily of proteins implicated in DNA repair and cell cycle checkpoint control. Mus101, which contains seven BRCT domains distributed throughout its length, is most similar to human TopBP1, a protein identified through its in vitro association with DNA topoisomerase IIbeta. Mus101 also shares sequence similarity with the fission yeast Rad4/Cut5 protein required for repair, replication, and checkpoint control, suggesting that the two proteins may be functional homologs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.