ArticleGenetics2000
Involvement of very short DNA tandem repeats and the influence of the RAD52 gene on the occurrence of deletions in Saccharomyces cerevisiae.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- DNA Damage and Its Role in Cancer Therapeutics.International journal of molecular sciences · 2023Review
- Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions.PLoS genetics · 2020Article
- Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma.Oncoscience · 2015Article
- Ploidy influences cellular responses to gross chromosomal rearrangements in Saccharomyces cerevisiae.BMC genomics · 2011Article
- Influence of genetic background on the occurrence of chromosomal rearrangements in Saccharomyces cerevisiae.BMC genomics · 2009Article
- MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings.Trends in genetics : TIG · 2008Review
- Adaptive evolution by mutations in the FLO11 gene.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Duplication processes in Saccharomyces cerevisiae haploid strains.Nucleic acids research · 2005Article
- Polymorphisms in the Chlamydia trachomatis cytotoxin locus associated with ocular and genital isolates.Infection and immunity · 2004Article
- Expansion and contraction of the DUP240 multigene family in Saccharomyces cerevisiae populations.Genetics · 2004Article
- Recovery of a function involving gene duplication by retroposition in Saccharomyces cerevisiae.Genome research · 2004Article
- Dissecting the pet18 mutation in Saccharomyces cerevisiae: HTL1 encodes a 7-kDa polypeptide that interacts with components of the RSC complex.Molecular genetics and genomics : MGG · 2003Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal rearrangements, such as deletions, duplications, or Ty transposition, are rare events. We devised a method to select for such events as Ura(+) revertants of a particular ura2 mutant. Among 133 Ura(+) revertants, 14 were identified as the result of a deletion in URA2. Of seven classes of deletions, six had very short regions of identity at their junctions (from 7 to 13 bp long). This strongly suggests a nonhomologous recombination mechanism for the formation of these deletions. The total Ura(+) reversion rate was increased 4.2-fold in a rad52Delta strain compared to the wild type, and the deletion rate was significantly increased. All the deletions selected in the rad52Delta context had microhomologies at their junctions. We propose two mechanisms to explain the occurrence of these deletions and discuss the role of microhomology stretches in the formation of fusion proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.