ArticleClinical and experimental immunology2000
Induction of necrosis and apoptosis of neutrophil granulocytes by Streptococcus pneumoniae.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 88 citations in OpenAlex.
- Article
- Different bacterial cargo in apoptotic cells drive distinct macrophage phenotypes.Apoptosis : an international journal on programmed cell death · 2024Article
- Contribution of Puma to Inflammatory Resolution During Early Pneumococcal Pneumonia.Frontiers in cellular and infection microbiology · 2022Article
- Transcriptome Profiling Reveals CD73 and Age-Driven Changes in Neutrophil Responses against Streptococcus pneumoniae.Infection and immunity · 2021Article
- Testing Anti-Pneumococcal Antibody Function Using Bacteria and Primary Neutrophils.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Role of astroglial Connexin 43 in pneumolysin cytotoxicity and during pneumococcal meningitis.PLoS pathogens · 2020Article
- Extracellular adenosine enhances the ability of PMNs to kill Streptococcus pneumoniae by inhibiting IL-10 production.Journal of leukocyte biology · 2020Article
- Hemocyte-hemocyte adhesion by granulocytes is associated with cellular immunity in the cricket, Gryllus bimaculatus.Scientific reports · 2019Article
- Group AMicrobiology spectrum · 2019Article
- Article
- Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis.Journal of neuroinflammation · 2017Article
- Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients.Molecular vision · 2017Article
- Pyruvate oxidase of Streptococcus pneumoniae contributes to pneumolysin release.BMC microbiology · 2016Article
- Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mcl-1 is vital for neutrophil survival.Immunologic research · 2015Review
- Bacterial fitness shapes the population dynamics of antibiotic-resistant and -susceptible bacteria in a model of combined antibiotic and anti-virulence treatment.Journal of theoretical biology · 2015Article
- Trehalose does not affect the functions of human neutrophils in vitro.Surgery today · 2014Article
- Regulation of human neutrophil apoptosis and lifespan in health and disease.Journal of cell death · 2014Review
- Subterfuge and sabotage: evasion of host innate defenses by invasive gram-positive bacterial pathogens.Annual review of microbiology · 2014Review
- The significance of caspase-cleaved cytokeratin 18 in pleural effusion.Tuberculosis and respiratory diseases · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptosis followed by macrophage phagocytosis is the principal mechanism by which neutrophil granulocytes (PMN) are removed from the site of inflammation. To investigate whether Streptococcus pneumoniae causes apoptosis of PMN, we exposed PMN to viable and heat-killed pneumococci and purified pneumococcal cell walls (PCW). The occurrence of PMN cell death was quantified by flow cytometry using annexin V/propidium iodide labelling of the cells. Intracellular histone-associated DNA fragments were quantified by ELISA. The presence of apoptosis was confirmed by in situ tailing. Exposure of PMN to viable pneumococci caused necrosis of the cells. The pneumococcal cytotoxin pneumolysin, the bacterial production of hydrogen peroxide, and PCW contributed to necrosis. Heat-killed pneumococci accelerated the process of apoptosis observed in cultivated non-stimulated PMN in vitro. These results demonstrated that pneumococci induce PMN cell death. Depending on the intensity of the stimulus, PMN necrosis and apoptosis were observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.