ArticleClinical and experimental immunology2000
Atopic eczema is associated with delayed maturation of the antibody response to pneumococcal vaccine.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Pooled it
- Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine.BMC infectious diseases · 2016Trial
- Recent Topics of Pneumococcal Vaccination: Indication of Pneumococcal Vaccine for Individuals at a Risk of Pneumococcal Disease in Adults.Microorganisms · 2021Review
- Association between nasal and nasopharyngeal bacterial colonization in early life and eczema phenotypes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Association between asthma and invasive pneumococcal disease risk: a systematic review and meta-analysis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Review
- Relationship between asthma status and antibody response pattern to 23-valent pneumococcal vaccination.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Article
- Adult Atopic Dermatitis with Comorbid Atopic Disease is Associated with Increased Risk of Infections: A Population-Based Cross-Sectional Study.Dermatology and therapy · 2017Article
- Article
- Injection Site Lichenoid Dermatitis Following Pneumococcal Vaccination: Report and Review of Cutaneous Conditions Occurring at Vaccination Sites.Dermatology and therapy · 2016Article
- Risks for infection in patients with asthma (or other atopic conditions): is asthma more than a chronic airway disease?The Journal of allergy and clinical immunology · 2014Review
- What does tympanostomy tube placement in children teach us about the association between atopic conditions and otitis media?Current allergy and asthma reports · 2014Review
- Agammaglobulinemia and lack of immunization protection in exudative atopic dermatitis.European journal of pediatrics · 2014Article
- Elucidation of pathways driving asthma pathogenesis: development of a systems-level analytic strategy.Frontiers in immunology · 2014Review
- Cellular immune response in young children accounts for recurrent acute otitis media.Current allergy and asthma reports · 2013Review
- Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility?The Journal of allergy and clinical immunology · 2012Review
- [Vaccinations with atopic dermatitis and other chronic inflammatory skin diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2010Article
- Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma.The Journal of allergy and clinical immunology · 2010Article
- Increased risk of serious pneumococcal disease in patients with asthma.The Journal of allergy and clinical immunology · 2008Article
- No influence of atopic diseases on antibody titres following tetanus, diphtheria and hepatitis B immunisation among adults.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2007Article
- Allergic sensitization and microbial load--a comparison between Finland and Russian Karelia.Clinical and experimental immunology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate a previously undocumented observation, that children with atopic eczema under 9 years of age tended to have a poor antibody response to Pneumococcal vaccination. Thirty-five children (mean age 8.8 years, range 3-16 years) with moderate to severe atopic eczema but no history of systemic infection were studied retrospectively. Pneumococcal antibody responses after immunization with Pneumovax II were compared with a hospital control group consisting of 36 children (mean age 6.0 years, range 3-16 years) with recurrent upper respiratory tract infections. Only 17% of children with atopic eczema aged 3-8 years responded to Pneumovax. This response was significantly poorer than that of the controls (57%) (odds ratio 0.20, 95% confidence interval (CI) 0.05-0.84, P = 0.03). There were no significant differences in the levels of total IgG2, the component of IgG associated with protective antibody responses to Pneumococcus between the two groups. Delay in maturation of the total IgG and IgG2 antibody response to Pneumococcus is a feature in this group of children with moderately severe atopic eczema.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.