Trial reportAmerican heart journal2000
Cardiac structure and function in fetuses of mothers infected with HIV: the prospective PCHIV multicenter study.
Trial report in American heart journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005274 (Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection), which is not on this map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2)
Who cites it
7 citing papers in PubMed, 49 citations in OpenAlex.
- Fetal cardiac evaluation in HIV-positive women under HAART therapy in a Romanian hospital.Experimental and therapeutic medicine · 2021Article
- Myocardial peak systolic velocity-a tool for cardiac screening of HIV-exposed uninfected children.European journal of pediatrics · 2020Observational
- Cardiac effects in perinatally HIV-infected and HIV-exposed but uninfected children and adolescents: a view from the United States of America.Journal of the International AIDS Society · 2013Review
- A case of transposition of the great arteries in a female infant of a HIV-1-infected woman. Potential teratogenic effects of antiretroviral drugs.Internal and emergency medicine · 2006Article
- A neonate with macrosomia, cardiomyopathy and hepatomegaly born to an HIV-infected mother.European journal of pediatrics · 2005Article
- Childbirth Education for the HIV-Positive Woman.The Journal of perinatal education · 2003Article
- Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study.Lancet (London, England) · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThis study was designed to determine if vertically transmitted HIV infection and maternal infection with HIV are associated with altered cardiovascular structure and function in utero.
methodsFetal echocardiography was performed in 173 fetuses of 169 HIV-infected mothers (mean gestational age, 33.0 weeks; SD = 3.7 weeks) at 5 centers. Biparietal diameter, femur length, cardiovascular dimensions, and Doppler velocities through atrioventricular and semilunar valves and the umbilical artery were measured. Measurements were converted to z scores based on published normal data.
resultsFetuses determined after birth to be HIV-infected had similar echocardiographic findings as fetuses later determined to be HIV-uninfected except for slightly smaller left ventricular diastolic dimensions (P =.01). The femur length (P =.03) was also smaller in the fetuses postnatally identified as HIV-infected. Differences in cardiovascular dimensions and Doppler velocities were identified between fetuses of HIV-infected women and previously published normal fetal data. The reason for the differences may be a result of maternal HIV infection, maternal risk factors, or selection bias in the external control data.
conclusionsVertically transmitted HIV infection may be associated with reduced left ventricular size but not with altered cardiac function in utero. Fetuses of HIV-infected mothers may have abnormal cardiovascular structure and function and increased placental vascular resistance, regardless of whether the fetuses are subsequently found to be infected with HIV.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.