ArticleApplied and environmental microbiology2000
Biochemical and genetic characterization of propionicin T1, a new bacteriocin from Propionibacterium thoenii.
Article in Applied and environmental microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 63 citations in OpenAlex.
- Genomic and Phenotypic Evaluation of Potential Probiotic Pediococcus Strains with Hypocholesterolemic Effect Isolated from Traditional Fermented Food.Probiotics and antimicrobial proteins · 2022Article
- Article
- Propionibacterium spp.-source of propionic acid, vitamin B12, and other metabolites important for the industry.Applied microbiology and biotechnology · 2018Review
- Multifaceted attributes of dairy propionibacteria: a review.World journal of microbiology & biotechnology · 2012Review
- Transcription analysis of a lantibiotic gene cluster from Bifidobacterium longum DJO10A.Applied and environmental microbiology · 2011Article
- Correlation of the capsular phenotype in Propionibacterium freudenreichii with the level of expression of gtf, a unique polysaccharide synthase-encoding gene.Applied and environmental microbiology · 2010Article
- Construction of a reporter vector system for in vivo analysis of promoter activity in Propionibacterium freudenreichii.Applied and environmental microbiology · 2008Article
- Skin microbiota: a source of disease or defence?The British journal of dermatology · 2008Review
- Heterologous production of antimicrobial peptides in Propionibacterium freudenreichii.Applied and environmental microbiology · 2005Article
- Molecular and genetic characterization of propionicin F, a bacteriocin from Propionibacterium freudenreichii.Applied and environmental microbiology · 2004Article
- Prevalence of the genes encoding propionicin T1 and protease-activated antimicrobial peptide and their expression in classical propionibacteria.Applied and environmental microbiology · 2004Article
- An antimicrobial peptide is produced by extracellular processing of a protein from Propionibacterium jensenii.Journal of bacteriology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A collection of propionibacteria was screened for bacteriocin production. A new bacteriocin named propionicin T1 was isolated from two strains of Propionibacterium thoenii. This bacteriocin shows no sequence similarity to other bacteriocins. Propionicin T1 was active against all strains of Propionibacterium acidipropionici, Propionibacterium thoenii, and Propionibacterium jensenii tested and also against Lactobacillus sake NCDO 2714 but showed no activity against Propionibacterium freudenreichii. The bacteriocin was purified, and the N-terminal part of the peptide was determined with amino acid sequencing. The corresponding gene pctA was sequenced, and this revealed that propionicin T1 is produced as a prebacteriocin of 96 amino acids with a typical sec leader, which is processed to give a mature bacteriocin of 65 amino acids. An open reading frame encoding a protein of 424 amino acids was found 68 nucleotides downstream the stop codon of pctA. The N-terminal part of this putative protein shows strong similarity with the ATP-binding cassette of prokaryotic and eukaryotic ABC transporters, and this protein may be involved in self-protection against propionicin T1. Propionicin T1 is the first bacteriocin from propionibacteria that has been isolated and further characterized at the molecular level.
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