ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Transient NMDA receptor inactivation provides long-term protection to cultured cortical neurons from a variety of death signals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 87 citations in OpenAlex.
- The Role of Cardiac N-Methyl-D-Aspartate Receptors in Heart Conditioning-Effects on Heart Function and Oxidative Stress.Biomolecules · 2020Article
- The NMDA Receptor Antibody Paradox: A Possible Approach to Developing Immunotherapies Targeting the NMDA Receptor.Frontiers in neurology · 2020Review
- A role for astrocyte-derived amyloid β peptides in the degeneration of neurons in an animal model of temporal lobe epilepsy.Brain pathology (Zurich, Switzerland) · 2019Article
- Preconditioning in neuroprotection: From hypoxia to ischemia.Progress in neurobiology · 2017Review
- Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.Molecules (Basel, Switzerland) · 2017Article
- Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease.Frontiers in neuroscience · 2016Review
- Article
- Calpain-1 contributes to IgE-mediated mast cell activation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- From single target to multitarget/network therapeutics in Alzheimer's therapy.Pharmaceuticals (Basel, Switzerland) · 2014Article
- An Immunological Approach to Increase the Brain's Resilience to Insults.ISRN neuroscience · 2014Article
- Proteomic analysis of primary cultured rat cortical neurons in chemical ischemia.Neurochemical research · 2013Article
- Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment.Neurotoxicity research · 2013Article
- Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology.Journal of psychiatry & neuroscience : JPN · 2013Review
- Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections.British journal of pharmacology · 2012Review
- Aβ internalization by neurons and glia.International journal of Alzheimer's disease · 2011Article
- Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity.Journal of neurochemistry · 2009Article
- Elevated synaptic activity preconditions neurons against an in vitro model of ischemia.The Journal of biological chemistry · 2008Article
- Neuroprotective effects of memantine in a mouse model of retinal degeneration induced by rotenone.Brain research · 2008Article
- Pharmacodynamics of memantine: an update.Current neuropharmacology · 2008Article
- Killer proteases and little strokes--how the things that do not kill you make you stronger.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NMDA receptor antagonists, such as (+)-5-methyl-10, 11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate (MK-801), potently block glutamate-induced neuronal death in myriad in vitro cell models and effectively attenuate ischemic damage in vivo. In this report, a novel role for MK-801 and other NMDA receptor antagonists in preconditioning neurons to withstand a wide range of subsequent lethal insults is described. A brief 30 min exposure to 0.1 microM MK-801, applied up to 96 hr before a "lethal" insult, protected primary cortical neurons from a diverse group of neurotoxic agents, including NMDA, beta-amyloid, staurosporine, etoposide, and oxygen-glucose deprivation. This neuroprotective preconditioning by MK-801 arose from transient NMDA receptor inactivation, because the noncompetitive NMDA receptor antagonists memantine and nylindin and the competitive antagonist AP-5 gave similar effects. MK-801 protection was dependent on new protein synthesis during the first 2 hr, but not from 2 to 5 hr, after MK-801 exposure. The MK-801 transient did not alter the ability of NMDA to trigger normally lethal [Ca(2+)](i) influx 48 hr later, but it did block early downstream signaling events coupled to NMDA neurotoxicity, including PKC inactivation and the activation of calpain. Moreover, MK-801 protected neurons from staurosporine-induced apoptosis, although caspase activation in these cells was unimpeded. It is likely that the stress associated with transient inactivation of NMDA receptors triggered a rapid compensatory survival response that provided long-term protection from a spectrum of insults, inducing apoptotic and nonapoptotic death. The possibility that MK-801 preconditioning blocks an event common to seemingly diverse death mechanisms suggests it will be an important tool for obtaining a clearer understanding of the salient molecular events at work in neuronal death and survival pathways.
Indexed as
Identifiers
11007874PMC6772776W1625998218What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.