ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Selective regulation of N-type Ca channels by different combinations of G-protein beta/gamma subunits and RGS proteins.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina.Nature communications · 2023Article
- Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Regulation of Ca(V)2 calcium channels by G protein coupled receptors.Biochimica et biophysica acta · 2013Review
- Gβ2 and Gβ4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons.The Journal of physiology · 2012Article
- The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.Cell biochemistry and biophysics · 2009Review
- Structure, function, and localization of Gβ5-RGS complexes.Progress in molecular biology and translational science · 2009Review
- Multicolor BiFC analysis of competition among G protein beta and gamma subunit interactions.Methods (San Diego, Calif.) · 2008Article
- Motor coordination deficits in mice lacking RGS9.Brain research · 2008Article
- How regulators of G protein signaling achieve selective regulation.Journal of molecular biology · 2007Review
- G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Functional expression and FRET analysis of green fluorescent proteins fused to G-protein subunits in rat sympathetic neurons.The Journal of physiology · 2001Article
- The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- G protein modulation of CaV2 voltage-gated calcium channels.Channels (Austin, Tex.)Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We examined the effects of G-protein beta and gamma subunit heterodimers on human alpha(1B) (N-type) Ca channels expressed in HEK293 cells. All of the known beta subunits (beta1-beta5) produced voltage-dependent inhibition of alpha(1B) Ca channels, depending on the gamma subunit found in the heterodimer. beta1-beta4 subunits inhibited Ca channels when paired with gamma1-gamma3. However, beta5 subunits only produced inhibition when paired with gamma2. In contrast, heterodimers between beta5 subunits and RGS (regulators of G-protein signaling) proteins containing GGL domains did not produce inhibition of Ca channels. However, GGL domain-containing RGS proteins (e.g., RGS6 and RGS11) did block the ability of Gbeta5/gamma2 heterodimers to inhibit Ca channels. Because all of the G-protein beta subunits are found in the nervous system, we conclude that they may all potentially participate in Ca channel inhibition. The interaction of GGL-containing RGS proteins with Gbeta5gamma2 suggests a novel way in which Ca channels can be regulated.
Indexed as
Identifiers
11007869PMC6772774What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.