ArticleToxicological sciences : an official journal of the Society of Toxicology2000
Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- A Systematic Review on the Influences of Neurotoxicological Xenobiotic Compounds on Inhibitory Control.Frontiers in behavioral neuroscience · 2019Pooled it
- Pesticide exposure and neurodevelopmental outcomes: review of the epidemiologic and animal studies.Journal of toxicology and environmental health. Part B, Critical reviews · 2013Pooled it
- Prenatal Chlorpyrifos Exposure Induces Ovarian Toxicity in Rat Offspring: Modulatory Potential of Curcumin.Toxics · 2026Article
- Preconception and first trimester exposure to pesticides and associations with stillbirth.American journal of epidemiology · 2025Article
- Time after a peak-pesticide use period and neurobehavior among ecuadorian children and adolescents: The ESPINA study.Environmental research · 2022Article
- Associations of acetylcholinesterase activity with depression and anxiety symptoms among adolescents growing up near pesticide spray sites.International journal of hygiene and environmental health · 2019Article
- Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth.Environmental health perspectives · 2019Article
- Response to Juberg et al.Environmental health : a global access science source · 2019Article
- Letter to the editor regarding "safety of safety evaluation of pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl" by Mie et al. (environmental health. 2018. 17:77).Environmental health : a global access science source · 2019Article
- Safety of Safety Evaluation of Pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl.Environmental health : a global access science source · 2018Article
- Recommendations for harmonization of data collection and analysis of developmental neurotoxicity endpoints in regulatory guideline studies: Proceedings of workshops presented at Society of Toxicology and joint Teratology Society and Neurobehavioral Teratology Society meetings.Neurotoxicology and teratology · 2017Article
- Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms.Journal of neurochemistry · 2017Review
- Potential short-term neurobehavioral alterations in children associated with a peak pesticide spray season: The Mother's Day flower harvest in Ecuador.Neurotoxicology · 2017Article
- Article
- Increased gut permeability and bacterial translocation after chronic chlorpyrifos exposure in rats.PloS one · 2014Article
- Impact of chronic exposure to low doses of chlorpyrifos on the intestinal microbiota in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and in the rat.Environmental science and pollution research international · 2013Article
- Evaluation of epidemiology and animal data for risk assessment: chlorpyrifos developmental neurobehavioral outcomes.Journal of toxicology and environmental health. Part B, Critical reviews · 2012Review
- Potential effects of chlorpyrifos on fetal growth outcomes: implications for risk assessment.Journal of toxicology and environmental health. Part B, Critical reviews · 2012Review
- Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women.PloS one · 2011Article
- Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups.Environmental health : a global access science source · 2009Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Pregnant Sprague-Dawley rats were given chlorpyrifos (O:, O-diethyl-O:-[3,5,6-trichloro-2-pyridinyl] phosphorothioate; CPF) in corn oil by gavage from gestation day 6 (GD 6) through lactation day 10 (LD 10) at dosages of 0, 0.3, 1, or 5 mg/kg/day in a developmental neurotoxicity study that conformed to U.S. Environmental Protection Agency 1991 guidelines. GD 0 was the day when evidence of mating was observed and postnatal day 0 (PND 0) was the day of birth. Toxicity was limited to the highest dosage level (5 mg/kg/day) and, in the dams, consisted of muscle fasciculation, hyperpnea, and hyperreactivity. A nonsignificant overall trend toward weight gain and feed consumption was also observed in the high-dosage dams, with a statistically significant Group x Time interaction for reduced weight gain in the 5-mg/kg/day group near the end of gestation. Although many developmental indices were normal, pups from high-dosage dams had increased mortality soon after birth, gained weight more slowly than controls, and had several indications of slightly delayed maturation. The early deaths and delayed maturation were attributed to maternal toxicity, though a possible contributing role of direct pup toxicity in delayed development cannot be eliminated. In spite of the apparent delay in physical development, high-dosage pups tested just after weaning had normal learning and memory as tested on a T-maze spatial delayed-alternation task. Habituation, a primitive form of learning, was tested in 2 tasks (motor activity and auditory startle) and was not affected. No overt effects were noted in either dams or pups at 1 or 0.3 mg/kg/day. Based on these data, chlorpyrifos produced maternal and developmental toxicity in the 5-mg/kg/day-dosage group. There was no evidence of selective developmental neurotoxicity following exposure to chlorpyrifos.
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