Trial reportProceedings of the National Academy of Sciences of the United States of America2000
A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Role of IL-13 Genetic Variants in Signalling of Asthma.Inflammation · 2017Article
- Genotyping ofDisease markers · 2017Article
- Human genetic factors and respiratory syncytial virus disease severity.Clinical microbiology reviews · 2008Review
- The genetics of atopic dermatitis.Clinical reviews in allergy & immunology · 2007Review
- Mapping and identifying genes for asthma and psoriasis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Novel association suggests multiple independent QTLs within chromosome 5q21-33 region control variation in total humans IgE levels.Genes and immunity · 2003Article
- Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients.Journal of human genetics · 2003Article
- Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice.Genes and immunity · 2002Article
- The shape of the messenger: using protein structure information to design novel cytokine-based therapeutics.Current pharmaceutical design · 2002Review
- Interactions between genes and environmental factors in asthma and atopy: new developments.Respiratory research · 2002Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central problem of complex inheritance is to map oligogenes for disease susceptibility, integrating linkage and association over samples that differ in several ways. Combination of evidence over multiple samples with 1,037 families supports loci contributing to asthma susceptibility in the cytokine region on 5q [maximum logarithm of odds (lod) = 2.61 near IL-4], but no evidence for atopy. The principal problems with retrospective collaboration on linkage appear to have been solved, providing far more information than a single study. A multipoint lod table evaluated at commonly agreed reference loci is required for both collaboration and metaanalysis, but variations in ascertainment, pedigree structure, phenotype definition, and marker selection are tolerated. These methods are invariant with statistical methods that increase the power of lods and are applicable to all diseases, motivating collaboration rather than competition. In contrast to linkage, positional cloning by allelic association has yet to be extended to multiple samples, a prerequisite for efficient combination with linkage and the greatest current challenge to genetic epidemiology.
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Registered trials
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