Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed.

1. The Leishmania donovani Ortholog of the Glycosylphosphatidylinositol Anchor Biosynthesis Cofactor PBN1 Is Essential for Host Infection.mBio · 2022
   Article
2. Lipid profile of Trichinella papuae muscle-stage larvae.Scientific reports · 2020
   Article
3. Emerging therapeutic targets for treatment of leishmaniasis.Expert opinion on therapeutic targets · 2018
   Review
4. Antigenic variation in African trypanosomes.Molecular and biochemical parasitology · 2014
   Review
5. Identification and functional analysis of Trypanosoma cruzi genes that encode proteins of the glycosylphosphatidylinositol biosynthetic pathway.PLoS neglected tropical diseases · 2013
   Article
6. Lipid metabolism in Trypanosoma brucei.Molecular and biochemical parasitology · 2010
   Review
7. Drug targets in Leishmania.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2010
   Article
8. Subcellular targeting strategies for drug design and delivery.Nature reviews. Drug discovery · 2010
   Review
9. Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases.The Biochemical journal · 2008
   Article
10. Phosphatidylethanolamine in Trypanosoma brucei is organized in two separate pools and is synthesized exclusively by the Kennedy pathway.The Journal of biological chemistry · 2008
    Article
11. Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.Eukaryotic cell · 2007
    Article
12. Characterization of the inositol phosphorylceramide synthase activity from Trypanosoma cruzi.The Biochemical journal · 2005
    Article
13. PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.Molecular biology of the cell · 2003
    Article
14. GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits.Proceedings of the National Academy of Sciences of the United States of America · 2003
    Article
15. Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers.Eukaryotic cell · 2003
    Article
16. Secretory pathway of trypanosomatid parasites.Microbiology and molecular biology reviews : MMBR · 2002
    Review
17. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8.The EMBO journal · 2001
    Article
18. Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.The EMBO journal · 2001
    Article

Corrections and comments

• Comment on
  Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.2000
• Comment on
  Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei.2000

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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