ArticleNeoplasia (New York, N.Y.)
HGF/SF activates glycolysis and oxidative phosphorylation in DA3 murine mammary cancer cells.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts.International journal of molecular sciences · 2021Article
- In vivo detection of distal tumor glycolytic flux stimulated by hepatic ablation in a breast cancer model using hyperpolarizedMagnetic resonance imaging · 2021Article
- The Influence of Met Receptor Level on HGF-Induced Glycolytic Reprogramming in Head and Neck Squamous Cell Carcinoma.International journal of molecular sciences · 2020Article
- Analysis of progress and challenges for various patterns of c-MET-targeted molecular imaging: a systematic review.EJNMMI research · 2017Review
- To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection.Frontiers in cellular and infection microbiology · 2017Review
- HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Review
- Applications of NMR spectroscopy to systems biochemistry.Progress in nuclear magnetic resonance spectroscopy · 2016Review
- The motility-proliferation-metabolism interplay during metastatic invasion.Scientific reports · 2015Article
- Interplay Between HGF/SF-Met-Ras Signaling, Tumor Metabolism and Blood Flow as a Potential Target for Breast Cancer Therapy.Oncoscience · 2014Article
- The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.Cell metabolism · 2012Article
- mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.The Journal of clinical investigation · 2011Article
- HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers.Journal of cell science · 2010Article
- In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met.Neoplasia (New York, N.Y.) · 2006Article
- HGF/SF increases tumor blood volume: a novel tool for the in vivo functional molecular imaging of Met.Neoplasia (New York, N.Y.) · 2006Article
- Noninvasive real-time imaging of apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization.Neoplasia (New York, N.Y.)Article
- MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine growth factor which increases cellular motility and has also been implicated in tumor development and progression and in angiogenesis. Little is known about the metabolic alteration induced in cells following Met-HGF/SF signal transduction. The hypothesis that HGF/SF alters the energy metabolism of cancer cells was investigated in perfused DA3 murine mammary cancer cells by nuclear magnetic resonance (NMR) spectroscopy, oxygen and glucose consumption assays and confocal laser scanning microscopy (CLSM). 31P NMR demonstrated that HGF/SF induced remarkable alterations in phospholipid metabolites, and enhanced the rate of glucose phosphorylation (P < .05). 13C NMR measurements, using [13C1]-glucose-enriched medium, showed that HGS/SF reduced the steady state levels of glucose and elevated those of lactate (P < .05). In addition, HGF/SF treatment increased oxygen consumption from 0.58+/-0.02 to 0.71+/-0.03 micromol/hour per milligram protein (P < .05). However, it decreased CO2 levels, and attenuated pH decrease. The mechanisms of these unexpected effects were delineated by CLSM, using NAD(P)H fluorescence measurements, which showed that HGF/SF increased the oxidation of the mitochondrial NAD system. We propose that concomitant with induction of ruffling, HGF/SF enhances both the glycolytic and oxidative phosphorylation pathways of energy production.
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