ArticleCell stress & chaperones2000
Heat shock and arsenite induce expression of the nonclassical class I histocompatibility HLA-G gene in tumor cell lines.
Article in Cell stress & chaperones, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Natural Killer Cell Receptors and Endometriosis: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Harnessing the potential of HLA-G in cancer therapy: advances, challenges, and prospects.Journal of translational medicine · 2024Review
- Heat Shock Proteins and HSF1 in Cancer.Frontiers in oncology · 2022Review
- Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment.Frontiers in immunology · 2022Review
- Role of HLA-G in Viral Infections.Frontiers in immunology · 2022Review
- HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives.Frontiers in immunology · 2020Review
- The Autoimmune Regulator (Aire) transactivates HLA-G gene expression in thymic epithelial cells.Immunology · 2019Article
- Similarities Between Embryo Development and Cancer Process Suggest New Strategies for Research and Therapy of Tumors: A New Point of View.Frontiers in cell and developmental biology · 2019Article
- Roles of heat shock factor 1 beyond the heat shock response.Cellular and molecular life sciences : CMLS · 2018Review
- The genetic diversity within the 1.4 kb HLA-G 5' upstream regulatory region moderately impacts on cellular microenvironment responses.Scientific reports · 2018Article
- Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2.Oncotarget · 2016Article
- HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal Niche.Frontiers in immunology · 2015Review
- Impact of HLA-G analysis in prevention, diagnosis and treatment of pathological conditions.World journal of methodology · 2014Review
- Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity.Frontiers in immunology · 2014Article
- Transcriptional and posttranscriptional regulations of the HLA-G gene.Journal of immunology research · 2014Review
- The dual role of HLA-G in cancer.Journal of immunology research · 2014Review
- Some basic aspects of HLA-G biology.Journal of immunology research · 2014Review
- HLA-G regulators in cancer medicine: an outline of key requirements.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Review
- Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?Cellular and molecular life sciences : CMLS · 2011Review
- The role of HLA-G in immunity and hematopoiesis.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nonclassical histocompatibility class I gene HLA-G has a tissue-restricted expression. To explore mechanisms involved in HLA-G transcriptional regulation, we have investigated the effect of stress, including heat shock and arsenite treatment, on HLA-G expression in tumor cell lines. We show that stress induces an increase of the level of the different HLA-G alternative transcripts without affecting other MHC class I HLA-A, -B, -E, and -F transcripts. A heat shock element (HSE) that binds to heat shock factor 1 (HSF1) on stress conditions was further identified within the HLA-G promoter. Considering the ability of HLA-G to modulate the function of immunocompetent cells, we hypothesize a new feature of HLA-G as a signal regulating the immune response to stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.