ArticleThe British journal of ophthalmology2000
At what age could screening for familial retinoblastoma be stopped? A register based study 1945-98.
Article in The British journal of ophthalmology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating whole genome sequencing for rare diseases in newborn screening: evidence synthesis from a series of systematic reviews.Health technology assessment (Winchester, England) · 2025Pooled it
- At What Age Could Screening for Familial Retinoblastoma Be Discontinued? A Systematic Review.Cancers · 2021Article
- Retinoblastoma and Neuroblastoma Predisposition and Surveillance.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Review
- Preserving vision in retinoblastoma through early detection and intervention.Current oncology reports · 2012Article
- Familial retinoblastoma: fundus screening schedule impact and guideline proposal. A retrospective study.Eye (London, England) · 2011Article
- Stage of presentation and visual outcome of patients screened for familial retinoblastoma: nationwide registration in the Netherlands.The British journal of ophthalmology · 2006Article
- Retinoblastoma in older patients: A retrospective comparative analysis of 100 consecutive patients based on age.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate until what age children in families with retinoblastoma should be screened.
methodsA register based cohort (n= 685) study of Dutch retinoblastoma patients (1945-1998). The records of all familial hereditary retinoblastoma patients from 1945 were reviewed and the age at diagnosis and either they were screened from birth determined.
results75 patients had the familial hereditary form of retinoblastoma. The mean age at diagnosis in patients with fundus screening (n=50) from birth on was 4.9 months (median 1.9 months; range 1 day to 48 months). Thus, 4 years was the latest onset of familial retinoblastoma properly evaluated from birth. This mean age was significantly different (p<0.0001) from the mean age at diagnosis in patients without fundus screening (n=25) from birth (mean 17.2 months; median 10.0 months; range 1.5-63.0 months).
conclusionsOphthalmological screening of children and sibs at risk for familial hereditary retinoblastoma is recommended until the age of 4 years in order to detect retinoblastoma as early as possible.
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