ArticleMolecular and cellular biology2000
Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Comprehensive regulation of γ-globin expression by epigenetic modifications and protein post-translational modifications.Clinical epigenetics · 2025Review
- TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer.Cancer metastasis reviews · 2024Review
- Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis.Nucleic acids research · 2018Article
- Article
- Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells.Molecular and cellular biology · 2015Article
- Screening of Transcription Factors Involved in Fetal Hemoglobin Regulation Using Phylogenetic Footprinting.Evolutionary bioinformatics online · 2015Article
- Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.Nature · 2014Article
- Human fetal globin gene expression is regulated by LYAR.Nucleic acids research · 2014Article
- Tissue-restricted transcription from a conserved intragenic CpG island in the Klf1 gene in mice.Biology of reproduction · 2012Article
- Article
- The transcription factor LSF: a novel oncogene for hepatocellular carcinoma.American journal of cancer research · 2012Article
- Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion.Developmental biology · 2011Article
- Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.PloS one · 2011Article
- PIAS1 regulates CP2c localization and active promoter complex formation in erythroid cell-specific alpha-globin expression.Nucleic acids research · 2010Article
- Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.Molecular and cellular biology · 2010Article
- The evolutionary diversification of LSF and Grainyhead transcription factors preceded the radiation of basal animal lineages.BMC evolutionary biology · 2010Article
- Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1.The Journal of biological chemistry · 2010Article
- Advances in the understanding of haemoglobin switching.British journal of haematology · 2010Review
- The male-determining gene SRY is a hybrid of DGCR8 and SOX3, and is regulated by the transcription factor CP2.Molecular and cellular biochemistry · 2010Article
- Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The stage selector protein (SSP) is a heteromeric complex involved in preferential expression of the human gamma-globin genes in fetal-erythroid cells. We have previously identified the ubiquitous transcription factor CP2 as a component of this complex. Using the protein dimerization domain of CP2 in a yeast two-hybrid screen, we have cloned a novel gene, NF-E4, encoding the tissue-restricted component of the SSP. NF-E4 and CP2 coimmunoprecipitate from extract derived from a fetal-erythroid cell line, and antiserum to NF-E4 ablates binding of the SSP to the gamma promoter. NF-E4 is expressed in fetal liver, cord blood, and bone marrow and in the K562 and HEL cell lines, which constitutively express the fetal globin genes. Enforced expression of NF-E4 in K562 cells and primary erythroid progenitors induces endogenous fetal globin gene expression, suggesting a possible strategy for therapeutic intervention in the hemoglobinopathies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.