ArticleAmerican journal of physiology. Cell physiology2000
Alterations in expression of myosin and myosin light chain kinases in response to vascular injury.
Article in American journal of physiology. Cell physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Hypoxic modulation of fetal vascular MLCK abundance, localization, and function.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- In vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells.Microcirculation (New York, N.Y. : 1994) · 2019Article
- Inflammation and vascular smooth muscle cell dedifferentiation following carotid artery ligation.Physiological genomics · 2017Article
- Adult vascular smooth muscle cells in culture express neural stem cell markers typical of resident multipotent vascular stem cells.Cell and tissue research · 2014Article
- Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury.Vascular cell · 2014Article
- Article
- Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma.Investigative ophthalmology & visual science · 2011Article
- Perivascular delivery of blebbistatin reduces neointimal hyperplasia after carotid injury in the mouse.The Journal of pharmacology and experimental therapeutics · 2011Article
- Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Unilateral renal artery stenosis causes a chronic vascular inflammatory response in ApoE-/- mice.Transactions of the American Clinical and Climatological Association · 2010Article
- Dependence of myoblast fusion on a cortical actin wall and nonmuscle myosin IIA.Developmental biology · 2009Article
- Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues.American journal of physiology. Cell physiology · 2006Review
- Microarray analysis reveals novel gene expression changes associated with erectile dysfunction in diabetic rats.Physiological genomics · 2005Article
- A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK.The Journal of biological chemistry · 2002Article
- 220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns.American journal of physiology. Cell physiology · 2002Article
- Preliminary research on myosin light chain kinase in rabbit liver.World journal of gastroenterology · 2001Article
- Identification of a new form of death-associated protein kinase that promotes cell survival.The Journal of biological chemistry · 2001Article
- Telokin expression is restricted to smooth muscle tissues during mouse development.American journal of physiology. Cell physiology · 2001Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Histochemical analysis of balloon-injured rat carotid arteries revealed a coordinated expression of nonmuscle myosin heavy chain-A and -B (NM-A and NM-B) in response to injury. Expression of these nonmuscle myosin forms shifts from the media to the adventitia and intima. In contrast, expression of smooth muscle myosin heavy chain-1 (SM-1) within the media is not altered, whereas smooth muscle myosin heavy chain-2 (SM-2) expression declines. Western blotting shows a statistically significant increase in expression of NM-A that occurs within 6 h in response to carotid injury, suggesting this myosin form may be an appropriate experimental marker for proliferating, migrating cells in injured vessels. No overall change in the relative expression level of NM-B was detected, suggesting that compensatory declines in media expression are balanced by increases in the intima and adventitia. Expression of SM-1 did not change in response to injury, whereas the expression of SM-2 significantly declined between 24 h and 7 days. Expression of myosin light chain kinase is also negatively regulated, and the decline in its expression parallels downregulation of SM-2.
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