ArticleJournal of clinical pathology2000
Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stroma.
Article in Journal of clinical pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 83 citations in OpenAlex.
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- Interstitial Cells of Cajal-Origin, Distribution and Relationship with Gastrointestinal Tumors.Medicina (Kaunas, Lithuania) · 2022Review
- Review
- Increased CD34 in pancreatic islet negatively predict islet β-cell decrease in type1 diabetes model.Frontiers in physiology · 2022Article
- CD34+ Stromal Cells/Telocytes as a Source of Cancer-Associated Fibroblasts (CAFs) in Invasive Lobular Carcinoma of the Breast.International journal of molecular sciences · 2021Article
- Expression of CD34 and α-SMA Markers in Oral Squamous Cell Carcinoma Differentiation. A Histological and Histo-Chemical Study.International journal of environmental research and public health · 2020Article
- Presence/Absence and Specific Location of Resident CD34+ Stromal Cells/Telocytes Condition Stromal Cell Development in Repair and Tumors.Frontiers in cell and developmental biology · 2020Article
- Role of VEGF, CD105, and CD31 in the Prognosis of Colorectal Cancer Cases.Journal of gastrointestinal cancer · 2019Article
- Clinicopathological significance of cancer-associated fibroblasts in papillary thyroid carcinoma: a predictive marker of cervical lymph node metastasis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
- Vasculo-smooth muscle hamartomatous structure is linked to morphogenesis of colorectal polypoid adenoma.Medical molecular morphology · 2015Article
- Telocytes are reduced during fibrotic remodelling of the colonic wall in ulcerative colitis.Journal of cellular and molecular medicine · 2015Article
- Concise review: evidence for CD34 as a common marker for diverse progenitors.Stem cells (Dayton, Ohio) · 2014Review
- Expression and role of fibroblast activation protein-alpha in microinvasive breast carcinoma.Diagnostic pathology · 2011Article
- CD34-positive stem cells: in the treatment of heart and vascular disease in human beings.Texas Heart Institute journal · 2011Review
- Estrogen signaling in colorectal carcinoma microenvironment: expression of ERbeta1, AIB-1, and TIF-2 is upregulated in cancer-associated myofibroblasts and correlates with disease progression.Virchows Archiv : an international journal of pathology · 2009Article
- Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with better [corrected] prognosis.Virchows Archiv : an international journal of pathology · 2009Article
- CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin.Virchows Archiv : an international journal of pathology · 2008Article
- CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder.Virchows Archiv : an international journal of pathology · 2007Article
- Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis.Immunologic research · 2006Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the role of CD34 positive stromal cells, namely dendritic interstitial cells, in the desmoplastic stroma formation of malignant epithelial neoplasms the distribution of CD34 positive stromal cells was examined in human colorectal adenocarcinomas, peritumoral inflammatory tissue, and normal tissue.
methodsForty one surgically resected human colorectal adenocarcinomas and their corresponding peritumoral inflammatory and normal tissues were examined. To distinguish CD34 positive stromal cells from vascular endothelial cells, immunostaining for both CD34 and CD31 was performed. The distribution of myofibroblasts was also analysed immunohistochemically, and double staining with CD34 and alpha smooth muscle actin (ASMA) was performed.
resultsMost of the stromal cells in the normal colorectal submucosa, muscularis propria, subserosa, and perirectal tissue were positive for CD34. In contrast, the peritumoral inflammatory tissue and the tumour stroma had no CD34 positive stromal cells. The distribution of myofibroblasts was almost the same as in the aforementioned series. No stromal cells double positive for CD34 and ASMA were detected in the peritumoral inflammatory tissues.
conclusionsMost stromal fibroblasts are CD34 positive stromal cells (dendritic interstitial cells). In colorectal adenocarcinomas, a lack of CD34 expression in stromal cells is associated with desmoplastic reaction.
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