ArticleOncogene2000
Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- Reciprocal compensation of caspase-2 and p53 regulates the DNA damage response in HCT116 colon cancer cells.The Journal of biological chemistry · 2026Article
- Canonical and non-canonical functions of p53 isoforms: potentiating the complexity of tumor development and therapy resistance.Cell death & disease · 2024Review
- PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives.Cancer management and research · 2020Review
- Transcriptional activation of p21Oncotarget · 2018Article
- Homologous recombination defects and how they affect replication fork maintenance.AIMS genetics · 2018Review
- p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage.Cell research · 2015Article
- Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ).Sub-cellular biochemistry · 2014Review
- p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation.Oncogene · 2013Article
- Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides.BMC molecular biology · 2007Article
- Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes.Oncogene · 2005Article
- The interaction of p53 with replication protein A mediates suppression of homologous recombination.Oncogene · 2004Article
- p53 protects from replication-associated DNA double-strand breaks in mammalian cells.Oncogene · 2004Article
- Discriminatory suppression of homologous recombination by p53.Nucleic acids research · 2004Article
- Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells.Nucleic acids research · 2004Article
- p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair.Oncogene · 2003Article
- BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous work (Dudenhöffer et al., 1999) unveiled a link between the capacity of p53 to regulate homologous recombination processes and to specifically bind to heteroduplex junction DNAs. Here, we show that p53 participates in ternary complex formation after preassembly of nucleoproteins, consisting of the human recombinase hRad51 and junction DNA. The cancer-related mutant p53(273H), which is defective in inhibiting recombination processes, displays a reduced capacity to associate with hRad51-DNA complexes, even under conditions which support DNA-binding. This suggests that hRad51-p53 contacts play a role in targeting p53 to heteroduplex joints and indicates an involvement in recombination immediately following hRad51-mediated strand transfer. To study the initial phase of strand exchange, when heteroduplex joints arise, we applied oligonucleotide based strand transfer assays. We observed that hRad51 stimulates exonucleolytic DNA degradation by p53, when it generates strand transfer intermediates. In agreement with this observation, artificial 3-stranded junction DNAs, designed to mimic nascent recombination intermediates, were found to represent preferred exonuclease substrates, especially when comprising a mismatch within the heteroduplex part. From our data, we propose a model according to which, p53-dependent correction of DNA exchange events is triggered by high-affinity binding to joint molecules and by stabilizing contacts with hRad51 oligomers. Oncogene (2000) 19, 4500 - 4512.
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