ArticleAmerican journal of human genetics2000
Localization of a small genomic region associated with elevated ACE.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypertension in Blacks of West African Origin
Genetics of Hypertension in Blacks
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Increased susceptibility of sepsis associated with CD143 deletion/insertion polymorphism in Caucasians: a meta analysis.International journal of clinical and experimental pathology · 2014Pooled it
- Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.Journal of hypertension · 2007Trial
- The Race for ACE: Targeting Angiotensin-Converting Enzymes (ACE) in SARS-CoV-2 Infection.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2022Review
- Association study indicates combined effect of interleukin-10 and angiotensin-converting enzyme in basal cell carcinoma development.Archives of dermatological research · 2021Observational
- High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pressure.Journal of the American Heart Association · 2017Article
- Genome-wide estimation of linkage disequilibrium from population-level high-throughput sequencing data.Genetics · 2014Article
- Renal angiotensin II type 1 receptor expression and associated hypertension in rats with minimal SHR nuclear genome.Physiological reports · 2013Article
- Article
- Fine-mapping angiotensin-converting enzyme gene: separate QTLs identified for hypertension and for ACE activity.PloS one · 2013Article
- Article
- Angiotensin-converting enzyme insertion/deletion polymorphism is associated with severe hypoxemia in pediatric ARDS.Intensive care medicine · 2012Article
- Haplotype variation in the ACE gene in global populations, with special reference to India, and an alternative model of evolution of haplotypes.The HUGO journal · 2011Article
- Genome-wide association studies: implications for multiethnic samples.Human molecular genetics · 2008Review
- Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome.Intensive care medicine · 2008Article
- A unified association analysis approach for family and unrelated samples correcting for stratification.American journal of human genetics · 2008Article
- Improving power in contrasting linkage-disequilibrium patterns between cases and controls.American journal of human genetics · 2007Article
- Genetics of arterial hypertension and hypotension.Naunyn-Schmiedeberg's archives of pharmacology · 2007Review
- An angiotensin converting enzyme haplotype predicts survival in patients with end stage renal disease.Human genetics · 2006Article
- A haplotype map of the human genome.Nature · 2005Article
- Association between evolutionary history of angiotensinogen haplotypes and plasma levels.Human genetics · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Defining the relationship between multiple polymorphisms in a small genomic region and an underlying quantitative trait locus (QTL) represents a major challenge in human genetics. Pedigree analyses have shown that angiotensin I-converting enzyme (ACE) levels are influenced by a QTL located within or close to the ACE gene and most likely resides in the 3' region of this locus. We genotyped seven polymorphisms spanning 13 kb in the 3' end of ACE in 159 Afro-Caribbean subjects to evaluate the linkage disequilibrium between these sites and to narrow the genomic region associated with an elevated ACE level using a cladistic analysis. The linkage disequilibrium measurement D' and a haplotype tree revealed three distinct haplotype segments, presumably because of recombination. The value of the linkage disequilibrium parameter p(excess) was highest for site 22982, which is located in the middle segment. A series of nested, cladistic analyses confirmed that the other two regions are unlikely to be the ACE-linked QTL and that the variant resides in the middle region. Analyses of the same polymorphisms in 98 unrelated Europeans in the Monitoring Trends and Determinants in Cardiovascular Diseases (MONICA) study resulted in fewer haplotypes than were observed among the Afro-Caribbean subjects, suggesting that populations with greater genetic diversity may be especially informative for fine-scale mapping.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.