ArticleJournal of virology2000
Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Methodological landscape in the field of integration site identification of retroviruses and retroviral vectors.Frontiers in bioengineering and biotechnology · 2025Review
- Leukemia-specific delivery of mutant NOTCH1 targeted therapy.The Journal of experimental medicine · 2018Article
- Lessons Learned from Mouse Mammary Tumor Virus in Animal Models.ILAR journal · 2016Article
- Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers.Genes, chromosomes & cancer · 2012Article
- Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway.Oncology reports · 2012Article
- Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression.Acta pharmacologica Sinica · 2009Article
- The pattern of expression of Notch protein members in normal and pathological endometrium.Journal of anatomy · 2008Article
- MMTV infectious cycle and the contribution of virus-encoded proteins to transformation of mammary tissue.Journal of mammary gland biology and neoplasia · 2008Review
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- Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene.Journal of virology · 2005Article
- Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas.Journal of virology · 2003Article
- Is there a role for Notch signalling in human breast cancer?Breast cancer research : BCR · 2003Review
- Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to wild-type mouse mammary tumor virus (MMTV), the MMTV mutants with specific deletions in the U3 region of their long terminal repeats cause T-cell lymphomas. In 30% of T-cell lymphomas arising in BALB/c mice infected with MLA-MMTV, a leukemogenic MMTV mutant, we have found that MMTV proviruses were integrated into a short region of the Notch1 genome, so that truncated Notch1 transcripts encoding the transmembrane and the cytoplasmic domains of Notch1 protein could be expressed. Thus, Notch1 is a major target of provirus insertional mutagenesis in these T-cell lymphomas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.