ArticleJournal of virology2000
DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Orf Virus-Based Therapeutic Vaccine for Treatment of Papillomavirus-Induced Tumors.Journal of virology · 2020Article
- Recent advances in preclinical model systems for papillomaviruses.Virus research · 2017Review
- Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue.Virology · 2016Article
- A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections.PloS one · 2015Article
- Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus.Journal of virology · 2013Article
- Using HLA-A2.1 Transgenic Rabbit Model to Screen and Characterize New HLA-A2.1 Restricted Epitope DNA Vaccines.Journal of vaccines & vaccination · 2010Article
- Article
- Differences in methodology, but not differences in viral strain, account for variable experimental outcomes in laboratories utilizing the cottontail rabbit papillomavirus model.Journal of virological methods · 2010Article
- HPV as a model for the development of prophylactic and therapeutic cancer vaccines.Current molecular medicine · 2009Review
- Micro-scale devices for transdermal drug delivery.International journal of pharmaceutics · 2008Review
- Article
- Vaccination Against Cervical Cancer: Hopes and Realities.American journal of cancer (Auckland, N.Z.) · 2005Article
- The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo.Journal of virology · 2004Article
- Prevention of cervical cancer through papillomavirus vaccination.Nature reviews. Immunology · 2004Review
- Life cycle heterogeneity in animal models of human papillomavirus-associated disease.Journal of virology · 2002Article
- Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits.Journal of virology · 2002Article
- Low-volume jet injection for intradermal immunization in rabbits.BMC biotechnology · 2002Article
- Combination treatment with intralesional cidofovir and viral-DNA vaccination cures large cottontail rabbit papillomavirus-induced papillomas and reduces recurrences.Antimicrobial agents and chemotherapy · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Malignant progression is a life-threatening consequence of human papillomavirus-associated lesions. In this study, we tested the efficacy of papillomavirus early-gene-based vaccines for prevention of carcinoma development of papillomavirus-induced skin papillomas on rabbits. Rabbit skin papillomas were initiated by infection with cottontail rabbit papillomavirus (CRPV). The papillomas were allowed to grow for 3 months without any treatment intervention. Rabbits were then immunized by gene gun-mediated intracutaneous administration of four DNA plasmids encoding CRPV E1, E2, E6, and E7 genes, respectively. All eight control rabbits receiving vector alone developed invasive carcinoma within 8 to 13 months. In contrast, only two of eight vaccinated rabbits developed carcinoma at 12 and 15 months, respectively. Papilloma growth was suppressed in the majority of vaccinated rabbits but not completely eradicated. These results indicate that gene gun-mediated immunization with papillomavirus early genes may be a promising strategy for prevention of malignant progression of human papillomavirus-associated lesions in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.