ArticleJournal of virology2000
Structure-based moloney murine leukemia virus reverse transcriptase mutants with altered intracellular direct-repeat deletion frequencies.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Review
- Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.Nucleic acids research · 2013Article
- Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis.Nucleic acids research · 2013Article
- Moloney murine leukemia virus genomic RNA packaged in the absence of a full complement of wild type nucleocapsid protein.Virology · 2012Article
- The remarkable frequency of human immunodeficiency virus type 1 genetic recombination.Microbiology and molecular biology reviews : MMBR · 2009Review
- Effects of identity minimization on Moloney murine leukemia virus template recognition and frequent tertiary template-directed insertions during nonhomologous recombination.Journal of virology · 2007Article
- Pausing during reverse transcription increases the rate of retroviral recombination.Journal of virology · 2006Article
- Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency.Journal of virology · 2004Article
- An RNA secondary structure bias for non-homologous reverse transcriptase-mediated deletions in vivo.Nucleic acids research · 2004Article
- Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis.Journal of virology · 2003Article
- Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo.Journal of virology · 2002Article
- RNase H activity is required for high-frequency repeat deletion during Moloney murine leukemia virus replication.Journal of virology · 2002Article
- Effects of limiting homology at the site of intermolecular recombinogenic template switching during Moloney murine leukemia virus replication.Journal of virology · 2001Article
- Dynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Template switching rates of Moloney murine leukemia virus reverse transcriptase mutants were tested using a retroviral vector-based direct-repeat deletion assay. The reverse transcriptase mutants contained alterations in residues that modeling of substrates into the catalytic core had suggested might affect interactions with primer and/or template strands. As assessed by the frequency of functional lacZ gene generation from vectors in which lacZ was disrupted by insertion of a sequence duplication, the frequency of template switching varied more than threefold among fully replication-competent mutants. Some mutants displayed deletion rates that were lower and others displayed rates that were higher than that of wild-type virus. Replication for the mutants with the most significant alterations in template switching frequencies was similar to that of the wild type. These data suggest that reverse transcriptase template switching rates can be altered significantly without destroying normal replication functions.
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