ReviewPlant molecular biology2000
RNA viruses as inducers, suppressors and targets of post-transcriptional gene silencing.
Review in Plant molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Resistance induction based on the understanding of molecular interactions between plant viruses and host plants.Virology journal · 2021Review
- Animal and human RNA viruses: genetic variability and ability to overcome vaccines.Archives of microbiology · 2021Review
- Viruses and viral proteins.IUCrJ · 2014Review
- Article
- Top 10 plant viruses in molecular plant pathology.Molecular plant pathology · 2011Review
- An intron sense suppression construct targeting soybean FAD2-1 requires a double-stranded RNA-producing inverted repeat T-DNA insert.Plant physiology · 2010Article
- RNA interference in infectious tropical diseases.The Korean journal of parasitology · 2008Review
- Strategies for functional validation of genes involved in reproductive stages of orchids.Plant physiology · 2007Article
- Amplicon-plus targeting technology (APTT) for rapid production of a highly unstable vaccine protein in tobacco plants.Plant molecular biology · 2007Article
- Ectopic DICER-LIKE1 expression in P1/HC-Pro Arabidopsis rescues phenotypic anomalies but not defects in microRNA and silencing pathways.The Plant cell · 2005Article
- Matrix attachment regions increase the efficiency and stability of RNA-mediated resistance to tomato spotted wilt virus in transgenic tobacco.Transgenic research · 2005Article
- Short interfering RNAs as a tool for cancer gene therapy.Cancer gene therapy · 2005Review
- Silencing of SARS-CoV spike gene by small interfering RNA in HEK 293T cells.Biochemical and biophysical research communications · 2004Article
- Tomato mosaic virus replication protein suppresses virus-targeted posttranscriptional gene silencing.Journal of virology · 2003Article
- In situ characterization of Cymbidium Ringspot Tombusvirus infection-induced posttranscriptional gene silencing in Nicotiana benthamiana.Journal of virology · 2003Article
- Agrobacterium-mediated plant transformation: the biology behind the "gene-jockeying" tool.Microbiology and molecular biology reviews : MMBR · 2003Review
- A viral protein inhibits the long range signaling activity of the gene silencing signal.The EMBO journal · 2002Article
- Transgenic plants expressing HC-Pro show enhanced virus sensitivity while silencing of the transgene results in resistance.Virus genes · 2002Article
- Transgene-mediated post-transcriptional gene silencing is inhibited by 3' non-coding sequences in Paramecium.Nucleic acids research · 2001Article
- HC-Pro suppression of transgene silencing eliminates the small RNAs but not transgene methylation or the mobile signal.The Plant cell · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-transcriptional gene silencing (PTGS) is a fundamental regulatory mechanism operating in diverse types of organisms, but the cellular components of the gene silencing machinery and the regulation of the process are not understood. Recent findings that cytoplasmically replicating RNA viruses act as both targets and inducers of PTGS has led to the idea that PTGS may have evolved as an anti-viral defense mechanism in plants. Consistent with this hypothesis, it has been found that certain plant viruses encode proteins that suppress PTGS. From a practical standpoint, an understanding of the mechanisms by which viruses regulate PTGS may well lead to better ways to control gene expression in plants. It is often desirable to overexpress selected beneficial genes or to silence detrimental ones in order to confer a particular phenotype. Induction of PTGS using RNA viruses as vectors or as transgenes provides a reliable and efficient way to interfere with the expression of a specific gene or with a family of genes. Conversely, expression of viral suppressors has significant potential to improve yields in technologies that use plants to express beneficial gene products. Given the antiviral nature of gene silencing in plants and the indications that PTGS is an ancient mechanism in eukaryotic organisms, understanding the phenomenon in plants could well lead to the development of anti-viral strategies in both plants and animals.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.