ReviewPlant molecular biology2000
Systemic silencing signal(s).
Review in Plant molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 93 citations in OpenAlex.
- Graft transmission of RNA silencing to non-transgenic scions for conferring virus resistance in tobacco.PloS one · 2013Article
- A dual strategy for the suppression of host antiviral silencing: two distinct suppressors for viral replication and viral movement encoded by potato virus M.Journal of virology · 2011Article
- RNA-dependent RNA polymerase 6 delays accumulation and precludes meristem invasion of a viroid that replicates in the nucleus.Journal of virology · 2010Article
- Plant responses against invasive nucleic acids: RNA silencing and its suppression by plant viral pathogens.Seminars in cell & developmental biology · 2009Review
- Defence-related gene expression in transgenic lemon plants producing an antimicrobial Trichoderma harzianum endochitinase during fungal infection.Transgenic research · 2008Article
- Tobacco mosaic virus movement protein enhances the spread of RNA silencing.PLoS pathogens · 2008Article
- Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation.PLoS genetics · 2007Article
- Analysis of transitive RNA silencing after grafting in transgenic plants with the coat protein gene of Sweet potato feathery mottle virus.Plant molecular biology · 2007Article
- Virus-induced gene silencing of argonaute genes in Nicotiana benthamiana demonstrates that extensive systemic silencing requires Argonaute1-like and Argonaute4-like genes.Plant physiology · 2006Article
- An RNA-dependent RNA polymerase prevents meristem invasion by potato virus X and is required for the activity but not the production of a systemic silencing signal.Plant physiology · 2005Article
- Grafting the way to the systemic silencing signal in plants.PLoS biology · 2004Article
- MicroRNA-directed cleavage of Nicotiana sylvestris PHAVOLUTA mRNA regulates the vascular cambium and structure of apical meristems.The Plant cell · 2004Article
- RNA interference: biology, mechanism, and applications.Microbiology and molecular biology reviews : MMBR · 2003Review
- The presence of a chromatin boundary appears to shield a transgene in tobacco from RNA silencing.The Plant cell · 2003Article
- Long-distance movement, virulence, and RNA silencing suppression controlled by a single protein in hordei- and potyviruses: complementary functions between virus families.Journal of virology · 2002Article
- High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.The Biochemical journal · 2002Article
- Induction of RNA interference in Caenorhabditis elegans by RNAs derived from plants exhibiting post-transcriptional gene silencing.Nucleic acids research · 2002Article
- A viral protein inhibits the long range signaling activity of the gene silencing signal.The EMBO journal · 2002Article
- RNA interference: advances and questions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grafting experiments have revealed that transgenic plants that undergo co-suppression of homologous transgenes and endogenous genes or PTGS of exogenous transgenes produce a sequence-specific systemic silencing signal that is able to propagate from cell to cell and at long distance. Similarly, infection of transgenic plants by viruses that carry (part of) a transgene sequence results in global silencing (VIGS) of the integrated transgenes although viral infection is localized. Systemic PTGS and VIGS strongly resemble recovery from virus infection in non-transgenic plants, leading to protection against secondary infection in newly emerging leaves and PTGS of transiently expressed homologous transgenes. The sequence-specific PTGS signal is probably a transgene product (for example, aberrant RNA) or a secondary product (for example, RNA molecules produced by an RNA-dependent RNA polymerase with transgene RNA as a matrix) that mimics the type of viral RNA that is targeted for degradation by cellular defence. Whether some particular cases of transgene TGS could also rely on the production of such a mobile molecule is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.