ReviewPlant molecular biology2000
Post-transcriptional gene silencing mutants.
Review in Plant molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Enhanced resistance to early blight in transgenic tomato lines expressing heterologous plant defense genes.Planta · 2005Article
- Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytes.Journal of virology · 2004Article
- RNA interference: antiviral weapon and beyond.World journal of gastroenterology · 2003Review
- Salicylic acid has cell-specific effects on tobacco mosaic virus replication and cell-to-cell movement.Plant physiology · 2002Article
- Nonsense-mediated decay of mutant waxy mRNA in rice.Plant physiology · 2001Article
- Transgene silencing in monocots.Plant molecular biology · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been known for more than a decade that increasing the gene copy number does not necessarily lead to increased gene activity. Plants have developed efficient mechanisms such as post-transcriptional gene silencing (PTGS) to regulate abnormal gene expression in a sequence-specific fashion. PTGS of (trans)genes can be inhibited by non-homologous viruses, and PTGS-impaired mutants can be hypersensitive to such viruses, indicating that in plants this mechanism is triggered to protect against viral invasion. Genetic analysis of a related phenomenon, quelling, in Neurospora has led to the identification of two genes encoding proteins that share homologies with RNA-dependent RNA polymerases and with DNA helicases. This finding reinforces previous models in which PTGS involves RNA molecules complementary to the RNA species targeted for degradation. Insight into the mechanisms of PTGS may also be obtained in other distant organisms such as Caenorhabditis elegans in which a related phenomenon, RNA interference, has been genetically studied, leading to the identification of two genes encoding proteins sharing homologies with a translation factor and an RNase D.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.