ReviewPlant molecular biology2000
RNA degradation and models for post-transcriptional gene-silencing.
Review in Plant molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 85 citations in OpenAlex.
- Generation of suspension cell cultures with high syringin content and anti-inflammatory activity through overexpressing glycotransferase SiUGT72BZ2 in Saussurea involucrata.Plant biotechnology journal · 2025Article
- Interaction between βC1 of satellite and coat protein of Chili leaf curl virus plays a crucial role in suppression of host RNA silencing.Applied microbiology and biotechnology · 2021Article
- Enhancement of Recombinant Protein Production in TransgenicInternational journal of molecular sciences · 2018Article
- Improvement of the transient expression system for production of recombinant proteins in plants.Scientific reports · 2018Article
- Accelerated triacylglycerol production and altered fatty acid composition in oleaginous microalga Neochloris oleoabundans by overexpression of diacylglycerol acyltransferase 2.Microbial cell factories · 2017Article
- Iron deficiency in barley plants: phytosiderophore release, iron translocation, and DNA methylation.Frontiers in plant science · 2015Article
- Gene technology for papaya ringspot virus disease management.TheScientificWorldJournal · 2014Review
- Expression of a functional human adenosine deaminase in transgenic tobacco plants.Transgenic research · 2013Article
- Transient co-expression of post-transcriptional gene silencing suppressors for increased in planta expression of a recombinant anthrax receptor fusion protein.International journal of molecular sciences · 2011Article
- Construction of efficient and effective transformation vectors for palmitoyl-acyl carrier protein thioesterase gene silencing in oil palm.Bioinformation · 2011Article
- Transgene constructs lacking transcription termination signal induce efficient silencing of endogenous targets in Arabidopsis.Molecular genetics and genomics : MGG · 2009Article
- The accumulation of oleosins determines the size of seed oilbodies in Arabidopsis.The Plant cell · 2006Article
- Iron accumulation does not parallel the high expression level of ferritin in transgenic rice seeds.Planta · 2005Article
- Identification of an RNA silencing suppressor from a plant double-stranded RNA virus.Journal of virology · 2005Article
- A genetic engineering strategy to eliminate peanut allergy.Current allergy and asthma reports · 2005Review
- Tissue-specific gene silencing mediated by a naturally occurring chalcone synthase gene cluster in Glycine max.The Plant cell · 2004Article
- The presence of a chromatin boundary appears to shield a transgene in tobacco from RNA silencing.The Plant cell · 2003Article
- Epigenetic interactions between Arabidopsis transgenes: characterization in light of transgene integration sites.Plant molecular biology · 2003Article
- Agrobacterium-mediated plant transformation: the biology behind the "gene-jockeying" tool.Microbiology and molecular biology reviews : MMBR · 2003Review
- Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases.BMC structural biology · 2003Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-transcriptional gene silencing (PTGS) is a form of stable but potentially reversible epigenetic modification, which frequently occurs in transgenic plants. The interaction in trans of genes with similar transcribed sequences results in sequence-specific degradation of RNAs derived from the genes involved. Highly expressed single-copy loci, transcribed inverted repeats, and poorly transcribed complex loci can act as sources of signals that trigger PTGS. In some cases, mobile, sequence-specific silencing signals can move from cell to cell or even over long distances in the plant. Several current models hold that silencing signals are 'aberrant' RNAs (aRNA), which differ in some way from normal mRNAs. The most likely candidates are small antisense RNAs (asRNA) and double-stranded RNAs (dsRNA). Direct evidence that these or other aRNAs found in silent tissues can induce PTGS is still lacking. Most current models assume that silencing signals interact with target RNAs in a sequence-specific fashion. This results in degradation, usually in the cytoplasm, by exonucleolytic as well as endonucleolytic pathways, which are not necessarily PTGS-specific. Biochemical-switch models hold that the silent state is maintained by a positive auto-regulatory loop. One possibility is that concentrations of hypothetical silencing signals above a critical threshold trigger their own production by self-replication, by degradation of target RNAs, or by a combination of both mechanisms. These models can account for the stability, reversibility and multiplicity of silent states; the strong influence of transcription rate of target genes on the incidence and stability of silencing, and the amplification and systemic propagation of motile silencing signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.