ReviewPlant molecular biology2000
Role of inverted DNA repeats in transcriptional and post-transcriptional gene silencing.
Review in Plant molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 167 citations in OpenAlex.
- Interplay between Agrobacterium T-DNA and backbone DNA in transgenic plant cells.Transgenic research · 2024Article
- Multiple integrations of a sense transgene, including a tandem inverted repeat confer stable RNA-silencing mediated virus resistance under different abiotic and biotic conditions.Transgenic research · 2023Article
- Nucleotide mismatches prevent intrinsic self-silencing of hpRNA transgenes to enhance RNAi stability in plants.Nature communications · 2022Article
- Inverted repeats in coronavirus SARS-CoV-2 genome manifest the evolution events.Journal of theoretical biology · 2021Article
- POU2F1 induces the immune escape in lung cancer by up-regulating PD-L1.American journal of translational research · 2021Article
- Single Molecule Imaging of T-DNA Intermediates FollowingInternational journal of molecular sciences · 2019Article
- Generic Repeat Finder: A High-Sensitivity Tool for Genome-Wide De Novo Repeat Detection.Plant physiology · 2019Article
- Generation of a selectable marker free, highly expressed single copy locus as landing pad for transgene stacking in sugarcane.Plant molecular biology · 2019Article
- 5-Azacytidine mediated reactivation of silenced transgenes in potato (Solanum tuberosum) at the whole plant level.Plant cell reports · 2017Article
- Lirex: A Package for Identification of Long Inverted Repeats in Genomes.Genomics, proteomics & bioinformatics · 2017Article
- Genomic variation and DNA repair associated with soybean transgenesis: a comparison to cultivars and mutagenized plants.BMC biotechnology · 2016Article
- Effects of a petunia scaffold/matrix attachment region on copy number dependency and stability of transgene expression in Nicotiana tabacum.Transgenic research · 2016Article
- ScaffoldScaffolder: solving contig orientation via bidirected to directed graph reduction.Bioinformatics (Oxford, England) · 2016Article
- Factors Determining the Efficiency of Porcine Somatic Cell Nuclear Transfer: Data Analysis with Over 200,000 Reconstructed Embryos.Cellular reprogramming · 2015Article
- Design and construction of an in-plant activation cassette for transgene expression and recombinant protein production in plants.Nature protocols · 2014Article
- Progressive 35S promoter methylation increases rapidly during vegetative development in transgenic Nicotiana attenuata plants.BMC plant biology · 2013Article
- Phosphorus starvation induces post-transcriptional CHS gene silencing in Petunia corolla.Plant cell reports · 2013Article
- Less is more: strategies to remove marker genes from transgenic plants.BMC biotechnology · 2013Review
- Editor's choice: Crop genome plasticity and its relevance to food and feed safety of genetically engineered breeding stacks.Plant physiology · 2012Review
- Coincident sequence-specific RNA degradation of linked transgenes in the plant genome.Plant molecular biology · 2012Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transgenes and endogenous genes are sensitive to silencing, in particular when the genes are tandemly repeated. Their expression can be transcriptionally or post-transcriptionally repressed, or both. It is remarkable that very often, two or more genes or parts of the genes are arranged as inverted repeats (IR). Many of such IRs are dominant silencing loci. They can repress the expression of homologous genes elsewhere in the genome in trans which is usually associated with an increase in the level of DNA methylation. Trans-silencing has been explained by DNA-DNA pairing between a repetitive silencing locus and a homologous target locus. However, there is accumulating evidence that the trans effect might be mediated by dsRNA transcribed from the IR (trans)genes. Besides dsRNA-directed DNA methylation, dsRNA in plants as well as in other systems also induces the degradation of homologous RNAs and silence genes post-transcriptionally. These findings indicate that several features associated with gene silencing can be attributed to the activities of dsRNA, which would explain why inverted transgene repeats are such efficient silencing loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.