ArticleThe Biochemical journal2000
Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- Regulatory mechanisms controlling store-operated calcium entry.Frontiers in physiology · 2023Review
- Distribution and Assembly of TRP Ion Channels.Advances in experimental medicine and biology · 2021Article
- Roles of transient receptor potential channels in regulation of vascular and epithelial barriers.Tissue barriers · 2017Article
- Canonical transient receptor potential channel 2 (TRPC2): old name-new games. Importance in regulating of rat thyroid cell physiology.Pflugers Archiv : European journal of physiology · 2014Review
- Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis.Experimental hematology · 2012Article
- Identification of two distinct genes at the vertebrate TRPC2 locus and their characterisation in a marsupial and a monotreme.BMC molecular biology · 2011Article
- Widespread losses of vomeronasal signal transduction in bats.Molecular biology and evolution · 2011Article
- TRPC expression in mesenchymal stem cells.Cellular & molecular biology letters · 2010Article
- International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family.Pharmacological reviews · 2010Review
- The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ.BMC neuroscience · 2010Article
- High-throughput microarray detection of vomeronasal receptor gene expression in rodents.Frontiers in neuroscience · 2010Article
- (Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Co-regulation of a large and rapidly evolving repertoire of odorant receptor genes.BMC neuroscience · 2007Review
- Calcium signaling phenomena in heart diseases: a perspective.Molecular and cellular biochemistry · 2007Review
- Homo- and heteromeric assembly of TRP channel subunits.Pflugers Archiv : European journal of physiology · 2005Article
- Neurobiology of TRPC2: from gene to behavior.Pflugers Archiv : European journal of physiology · 2005Review
- Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Transcriptional regulation and processing increase the functional variability of TRPM channels.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient receptor potential channels (TRPCs) are known as candidate molecular correlates of receptor-activated or store-operated calcium entry. While functional roles for most TRPCs have been suggested, the physiological relevance of TRPC2 remains obscure. Whereas human and bovine TRPC2 are candidate pseudogenes, full-length rodent TRPC2 transcripts have been reported. There is, however, considerable controversy concerning mRNA splicing, tissue distribution and the function of these proteins. We report the molecular cloning of two novel murine TRPC2 splice variants, mTRPC2alpha and mTRPC2beta. mTRPC2alpha RNA is expressed at low levels in many tissues and cell systems, while mTRPC2beta is exclusively and abundantly expressed in the vomeronasal organ (VNO). When expressed in human embryonic kidney (HEK)-293 cells, mTRPC2 did not enhance receptor- or store-activated calcium entry. In order to investigate the basis of such a functional defect, mTRPC2-green fluorescent protein fusion proteins were examined by confocal microscopy. Fusion proteins were retained in endomembranes when expressed in HEK-293 or other cells of epithelial or neuronal origin. Co-expression of TRPC2 with other TRPCs did not restore plasma-membrane trafficking. We conclude that TRPC2 may form functional channels in the cellular context of the VNO, but is unlikely to have a physiological function in other tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.