ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2000
Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed.
- Comparative Oligo-FISH Mapping Illuminates Chromosomal Evolution Among Rutaceae Species Diverged Over 50 Million Years.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Drift drives the evolution of chromosome number II: The impact of range size on genome evolution in Carnivora.The Journal of heredity · 2024Article
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- halSynteny: a fast, easy-to-use conserved synteny block construction method for multiple whole-genome alignments.GigaScience · 2020Article
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- Karyotype, evolution and phylogenetic reconstruction in Micronycterinae bats with implications for the ancestral karyotype of Phyllostomidae.BMC evolutionary biology · 2019Article
- Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks.Genome research · 2019Article
- Species identification of crested gibbons (Zoological research · 2018Article
- TiHo-0906: a new feline mammary cancer cell line with molecular, morphological, and immunocytological characteristics of epithelial to mesenchymal transition.Scientific reports · 2018Article
- Article
- Cat Mammary Tumors: Genetic Models for the Human Counterpart.Veterinary sciences · 2016Review
- Cytogenomics of Feline Cancers: Advances and Opportunities.Veterinary sciences · 2015Review
- 2D and 3D chromosome painting in malaria mosquitoes.Journal of visualized experiments : JoVE · 2014Article
- Chromosomal rearrangements and karyotype evolution in carnivores revealed by chromosome painting.Heredity · 2012Article
- High-resolution chromosome painting reveals the first genetic signature for the chiropteran suborder Pteropodiformes (Mammalia: Chiroptera).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae.Genomics · 2009Article
- Chromosomal rearrangements underlying karyotype differences between Chinese pangolin (Manis pentadactyla) and Malayan pangolin (Manis javanica) revealed by chromosome painting.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Chromosomal evolution of the PKD1 gene family in primates.BMC evolutionary biology · 2008Article
- Chromhome: a rich internet application for accessing comparative chromosome homology maps.BMC bioinformatics · 2008Article
- Chromosome painting shows that skunks (Mephitidae, Carnivora) have highly rearranged karyotypes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Domestic cats and dogs are important companion animals and model animals in biomedical research. The cat has a highly conserved karyotype, closely resembling the ancestral karyotype of mammals, while the dog has one of the most extensively rearranged mammalian karyotypes investigated so far. We have constructed the first detailed comparative chromosome map of the domestic dog and cat by reciprocal chromosome painting. Dog paints specific for the 38 autosomes and the X chromosomes delineated 68 conserved chromosomal segments in the cat, while reverse painting of cat probes onto red fox and dog chromosomes revealed 65 conserved segments. Most conserved segments on cat chromosomes also show a high degree of conservation in G-banding patterns compared with their canine counterparts. At least 47 chromosomal fissions (breaks), 25 fusions and one inversion are needed to convert the cat karyotype to that of the dog, confirming that extensive chromosome rearrangements differentiate the karyotypes of the cat and dog. Comparative analysis of the distribution patterns of conserved segments defined by dog paints on cat and human chromosomes has refined the human/cat comparative genome map and, most importantly, has revealed 15 cryptic inversions in seven large chromosomal regions of conserved synteny between humans and cats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.