ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Phenotypes of trpl mutants and interactions between the transient receptor potential (TRP) and TRP-like channels in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- A day sleep promoting role of phototransduction inNeurobiology of sleep and circadian rhythms · 2026Article
- AnInsects · 2023Article
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- Regulatory mechanisms controlling store-operated calcium entry.Frontiers in physiology · 2023Review
- A Non-Gradual Development Process of Cicada Eyes at the End of the Fifth-Instar Nymphal Stage to Obtain Visual Ability.Insects · 2022Article
- Transient Receptor Potential Channels: Important Players in Ocular Pain and Dry Eye Disease.Pharmaceutics · 2022Review
- Identification of VdASP F2-interacting protein as a regulator of microsclerotial formation in Verticillium dahliae.Microbial biotechnology · 2022Article
- Electrophysiological adaptations of insect photoreceptors and their elementary responses to diurnal and nocturnal lifestyles.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Sexual Transcription Differences inFrontiers in genetics · 2019Article
- A Single Residue Mutation in the GαG3 (Bethesda, Md.) · 2018Article
- EAG channels expressed in microvillar photoreceptors are unsuited to diurnal vision.The Journal of physiology · 2017Article
- Haeme oxygenase protects against UV light DNA damages in the retina in clock-dependent manner.Scientific reports · 2017Article
- The Phosphorylation State of theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Insect photoreceptor adaptations to night vision.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Distinct roles of light-activated channels TRP and TRPL in photoreceptors ofThe Journal of general physiology · 2017Article
- The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells.PLoS genetics · 2015Article
- Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy.Molecular and cellular biochemistry · 2015Article
- The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.PLoS biology · 2014Article
- Mutation of light-dependent phosphorylation sites of the Drosophila transient receptor potential-like (TRPL) ion channel affects its subcellular localization and stability.The Journal of biological chemistry · 2013Article
- Drosophila TRP channels and animal behavior.Life sciences · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The trp and trpl genes are thought to encode two classes of light-activated ion channels in Drosophila. A previous report indicated that a null trpl mutant does not display any mutant phenotype. This lack of detectable mutant phenotypes made it difficult to suggest functions for the transient receptor potential-like (TRPL) channel in photoreceptor responses. Here, the properties of trpl photoreceptor responses were studied by using electroretinogram (ERG) and intracellular recording techniques in combination with light stimuli of relatively long durations. Distinct mutant phenotypes were detectable under these conditions. These consisted of a reduced sustained component, oscillations superimposed on the response, a poststimulus hyperpolarization, and altered adaptation properties to dim background light. Comparison of photoreceptor responses obtained from wild type, trp, and trpl showed that the responses obtained from the trp and trpl null mutants did not sum up to that of the wild-type response. To explain the nonlinear summation at the peak of the response, Reuss et al. (1997) proposed that Ca(2+) ions entering through the TRP channel modulate TRP and TRPL channel activities differentially. However, nonlinear summation was present not only at the peak but throughout the duration of response. Two lines of evidence are presented to suggest that, in addition to the interaction proposed by Reuss et al. (1997), there are other forms of interactions between TRP and TRPL channels, probably involving the channel proteins themselves.
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10995823PMC6772831What OpenQuestion holds
Registered trials
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