ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Dependence of transient and residual calcium dynamics on action-potential patterning during neuropeptide secretion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- A Neurotensin Brake on Exploratory Drive under Persistent Threat.bioRxiv : the preprint server for biology · 2026Article
- Orexins and neuregulins as exemplars of peptide physiology in the brain: experimental challenges and implications for neuropathology.Frontiers in cellular neuroscience · 2026Article
- Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system.Pharmacological reviews · 2025Review
- Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Exploring the Therapeutic Effect of Neurotrophins and Neuropeptides in Neurodegenerative Diseases: at a Glance.Molecular neurobiology · 2023Review
- Local production of corticotropin-releasing hormone in prefrontal cortex modulates male-specific novelty exploration.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Stac protein regulates release of neuropeptides.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Efferent synaptic transmission at the vestibular type II hair cell synapse.Journal of neurophysiology · 2020Article
- Cell type- and pathway-specific synaptic regulation of orexin neurocircuitry.Brain research · 2020Review
- Article
- A Predictive, Quantitative Model of Spiking Activity and Stimulus-Secretion Coupling in Oxytocin Neurons.Endocrinology · 2018Article
- Endogenous opioids regulate moment-to-moment neuronal communication and excitability.Nature communications · 2017Article
- What optogenetic stimulation is telling us (and failing to tell us) about fast neurotransmitters and neuromodulators in brain circuits for wake-sleep regulation.Current opinion in neurobiology · 2014Article
- Spike triggered hormone secretion in vasopressin cells; a model investigation of mechanism and heterogeneous population function.PLoS computational biology · 2013Article
- Neuropeptide transmission in brain circuits.Neuron · 2012Review
- Voltage-dependent kappa-opioid modulation of action potential waveform-elicited calcium currents in neurohypophysial terminals.Journal of cellular physiology · 2010Article
- Long-lasting intrinsic optical changes observed in the neurointermediate lobe of the mouse pituitary reflect volume changes in cells of the pars intermedia.Neuroendocrinology · 2010Article
- Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Substance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers.Neuroscience · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Secretion of the neuropeptide arginine vasopressin (AVP) from the neurohypophysis is optimized by short phasic bursts of action potentials with a mean intraburst frequency around 10 Hz. Several hypotheses, most prominently action-potential broadening and buildup of residual calcium, have been proposed to explain this frequency dependence of AVP release. However, how either of these mechanisms would optimize release at any given frequency remains an open question. We have addressed this issue by correlating the frequency-dependence of intraterminal calcium dynamics and AVP release during action-potential stimulation. By monitoring the intraterminal calcium changes with low-affinity indicator dyes and millisecond time resolution, the signal could be dissected into three separate components: rapid Ca(2+) rises (Delta[Ca(2+)](tr)) related to action-potential depolarization, Ca(2+) extrusion and/or uptake, and a gradual increase in residual calcium (Delta[Ca(2+)](res)) throughout the stimulus train. Action-potential stimulation modulated all three components in a manner dependent on both the stimulation frequency and number of stimuli. Overall, the cumulative Delta[Ca(2+)](tr) amplitude initially increased with f(Stim) and then rapidly deteriorated, with a maximum around f(Stim) </= 5 Hz. Residual calcium levels, in contrast, increased monotonically with stimulation frequency. Simultaneously with the calcium measurements we determined the amount of AVP release evoked by each stimulus train. Hormone release increased with f(Stim) beyond the peak in Delta[Ca(2+)](tr) amplitudes, reaching its maximum between 5 and 10 Hz before returning to its 1 Hz level. Thus, AVP release responds to the temporal patterning of stimulation, is sensitive to both Delta[Ca(2+)](tr) and Delta[Ca(2+)](res), and is optimized at a frequency intermediate between the frequency-dependent maxima in Delta[Ca(2+)](tr) and Delta[Ca(2+)](res).
Indexed as
Identifiers
10995820PMC6772822W1563253256What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.