ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Direct energy consumption by inhibitory GABAFrontiers in neuroscience · 2026Article
- Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling.Cell reports · 2022Article
- Developmental Phase Transitions in Spatial Organization of Spontaneous Activity in Postnatal Barrel Cortex Layer 4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Atlastin-1 modulates seizure activity and neuronal excitability.CNS neuroscience & therapeutics · 2020Article
- α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Glycine Receptor Activation Impairs ATP-Induced Calcium Transients in Cultured Cortical Astrocytes.Frontiers in molecular neuroscience · 2017Article
- Association of Microtubule Dynamics with Chronic Epilepsy.Molecular neurobiology · 2016Article
- p75 regulates Purkinje cell firing by modulating SK channel activity through Rac1.The Journal of biological chemistry · 2014Article
- Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases.Frontiers in synaptic neuroscience · 2013Article
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- GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice.Nature medicine · 2011Article
- Bacterial toxins and the nervous system: neurotoxins and multipotential toxins interacting with neuronal cells.Toxins · 2010Review
- Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.The Journal of biological chemistry · 2009Article
- Genome-wide prediction of functional gene-gene interactions inferred from patterns of genetic differentiation in mice and men.PloS one · 2008Article
- The cytotoxic necrotizing factors from Yersinia pseudotuberculosis and from Escherichia coli bind to different cellular receptors but take the same route to the cytosol.Infection and immunity · 2007Article
- C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins.Naunyn-Schmiedeberg's archives of pharmacology · 2007Review
- Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the cytoskeleton in the activity of GABA(A) receptors was investigated in cultured hippocampal neurons. Receptor currents were measured with the whole-cell patch-clamp technique during repetitive stimulation with 1 microm muscimol. After destruction of the microtubular system with nocodazol, muscimol-induced currents showed a rundown by 78%. A similar rundown was observed when actin fibers were destroyed with latrunculin B or C2 toxin of Clostridium botulinum. Because the small GTPases of the Rho family RhoA, Rac1, and Cdc42 are known to control the organization of actin fibers, we investigated their possible involvement. Inactivation of the GTPases with clostridial toxins, as well as intracellular application of recombinant Rho GTPases, indicated that active Rac1 was necessary for full GABA(A) receptor activity. Immunocytochemical labeling of the receptors showed that the disappearance of receptor clusters in the somatic membrane as induced by muscimol stimulation was enhanced by Rac1 inactivation. It is suggested that Rac1 participates in the regulation of GABA(A) receptor clustering and/or recycling.
Indexed as
Identifiers
10995817PMC6772837W2138191175What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.