ArticleProceedings of the National Academy of Sciences of the United States of America2000
Adaptive evolution of a candidate gene for aging in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- G protein-coupled receptors that influence lifespan of human and animal models.Biogerontology · 2022Review
- Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.Molecular ecology · 2021Article
- Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster.Molecular ecology · 2021Article
- SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes.Frontiers in genetics · 2021Review
- Review
- A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila.Evolution; international journal of organic evolution · 2019Article
- An inversion supergene in Drosophila underpins latitudinal clines in survival traits.Journal of evolutionary biology · 2018Article
- Genome-Wide Analysis of Starvation-Selected Drosophila melanogaster-A Genetic Model of Obesity.Molecular biology and evolution · 2018Article
- Regulation of Drosophila Lifespan by bellwether Promoter Alleles.Scientific reports · 2017Article
- Comparative population genomics of latitudinal variation in Drosophila simulans and Drosophila melanogaster.Molecular ecology · 2016Article
- A recent global selective sweep on the age-1 phosphatidylinositol 3-OH kinase regulator of the insulin-like signaling pathway within Caenorhabditis remanei.G3 (Bethesda, Md.) · 2014Article
- Stressful environments can indirectly select for increased longevity.Ecology and evolution · 2014Article
- Modulation of methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance.Aging cell · 2013Article
- Neuronal inputs and outputs of aging and longevity.Frontiers in genetics · 2013Article
- Article
- Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America.Molecular ecology · 2012Article
- A de novo transcriptome of the Asian tiger mosquito, Aedes albopictus, to identify candidate transcripts for diapause preparation.BMC genomics · 2011Article
- Adaptations to climate-mediated selective pressures in humans.PLoS genetics · 2011Article
- Molecular population genetics and selection in the glycolytic pathway.The Journal of experimental biology · 2011Review
- Genomic differentiation between temperate and tropical Australian populations of Drosophila melanogaster.Genetics · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Examination of the phenotypic effects of specific mutations has been extensively used to identify candidate genes affecting traits of interest. However, such analyses do not reveal anything about the evolutionary forces acting at these loci, or whether standing allelic variation contributes to phenotypic variance in natural populations. The Drosophila gene methuselah (mth) has been proposed as having major effects on organismal stress response and longevity phenotype. Here, we examine patterns of polymorphism and divergence at mth in population level samples of Drosophila melanogaster, D. simulans, and D. yakuba. Mth has experienced an unusually high level of adaptive amino acid divergence concentrated in the intra- and extracellular loop domains of the receptor protein, suggesting the historical action of positive selection on those regions of the molecule that modulate signal transduction. Further analysis of single nucleotide polymorphisms (SNPs) in D. melanogaster provided evidence for contemporary and spatially variable selection at the mth locus. In ten surveyed populations, the most common mth haplotype exhibited a 40% cline in frequency that coincided with population level differences in multiple life-history traits including lifespan. This clinal pattern was not associated with any particular SNP in the coding region, indicating that selection is operating at a closely linked site that may be involved in gene expression. Together, these consistently nonneutral patterns of inter- and intraspecific variation suggest adaptive evolution of a signal transduction pathway that may modulate lifespan in nature.
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