ArticleProceedings of the National Academy of Sciences of the United States of America2000
Function of bicoid and hunchback homologs in the basal cyclorrhaphan fly Megaselia (Phoridae).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- Asymmetric chromatin accessibility underlies anterior-posterior axis specification in moth fly embryos.PLoS biology · 2026Article
- Genomic resources for the scuttle fly Megaselia abdita: a model organism for comparative developmental studies in flies.Development (Cambridge, England) · 2025Article
- Breaking anterior-posterior symmetry in the moth flybioRxiv : the preprint server for biology · 2025Article
- Advances in genome sequencing reveal changes in gene content that contribute to arthropod macroevolution.Development genes and evolution · 2023Review
- Twenty-seven ZAD-ZNF genes of Drosophila melanogaster are orthologous to the embryo polarity determining mosquito gene cucoid.PloS one · 2023Article
- Developing an integrated understanding of the evolution of arthropod segmentation using fossils and evo-devo.Proceedings. Biological sciences · 2019Article
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- Article
- Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle flyeLife · 2018Article
- Non-canonical dorsoventral patterning in the moth midgeEvoDevo · 2017Article
- Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies.eLife · 2016Article
- Gap Gene Regulatory Dynamics Evolve along a Genotype Network.Molecular biology and evolution · 2016Article
- Germ line transformation and in vivo labeling of nuclei in Diptera: report on Megaselia abdita (Phoridae) and Chironomus riparius (Chironomidae).Development genes and evolution · 2015Article
- Maternal co-ordinate gene regulation and axis polarity in the scuttle fly Megaselia abdita.PLoS genetics · 2015Article
- Article
- High-resolution gene expression data from blastoderm embryos of the scuttle fly Megaselia abdita.Scientific data · 2015Article
- SuperFly: a comparative database for quantified spatio-temporal gene expression patterns in early dipteran embryos.Nucleic acids research · 2015Article
- Article
- New genes as drivers of phenotypic evolution.Nature reviews. Genetics · 2013Review
- Comparative transcriptomics of early dipteran development.BMC genomics · 2013Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The Drosophila gene bicoid functions at the beginning of a gene cascade that specifies anterior structures in the embryo. Its transcripts are localized at the anterior pole of the oocyte, giving rise to a Bicoid protein gradient, which regulates the spatially restricted expression of target genes along the anterior-posterior axis of the embryo in a concentration-dependent manner. The morphogen function of Bicoid requires the coactivity of the zinc finger transcription factor Hunchback, which is expressed in a Bicoid-dependent fashion in the anterior half of the embryo. Whereas hunchback is conserved throughout insects, bicoid homologs are known only from cyclorrhaphan flies. Thus far, identification of hunchback and bicoid homologs rests only on sequence comparison. In this study, we used double-stranded RNA interference (RNAi) to address the function of bicoid and hunchback homologs in embryos of the lower cyclorrhaphan fly Megaselia abdita (Phoridae). Megaselia-hunchback RNAi causes hunchback-like phenotypes as observed in Drosophila, but Megaselia-bicoid RNAi causes phenotypes different from corresponding RNAi experiments in Drosophila and bicoid mutant embryos. Megaselia-bicoid is required not only for the head and thorax but also for the development of four abdominal segments. This difference between Megaselia and Drosophila suggests that the range of functional bicoid activity has been reduced in higher flies.
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