ArticleProceedings of the National Academy of Sciences of the United States of America2000
Leptin as a modulator of sweet taste sensitivities in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
113 citing papers in PubMed, 318 citations in OpenAlex.
- Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single-blind placebo-controlled study.Diabetes, obesity & metabolism · 2023Trial
- Pharmaceutical agents targeting KThe journal of physiological sciences : JPS · 2026Article
- Temperature effects on taste preferences are influenced by TRPM8.bioRxiv : the preprint server for biology · 2026Article
- Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons inNeuroscience insights · 2026Article
- The Role of Diet and Hormones on Taste: Low Carb Compared With Low Fat Study Findings.Current developments in nutrition · 2025Article
- Fat taste responsiveness, but not dietary fat intake, is affected inbioRxiv : the preprint server for biology · 2025Article
- Article
- Mechanisms and Functions of Sweet Reception in Oral and Extraoral Organs.International journal of molecular sciences · 2024Review
- Metabolic and feeding adjustments during pregnancy.Nature reviews. Endocrinology · 2023Review
- Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader-Willi syndrome.Obesity science & practice · 2023Article
- Adrenomedullin Enhances Mouse Gustatory Nerve Responses to Sugars via T1R-Independent Sweet Taste Pathway.Nutrients · 2023Article
- Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023Review
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Endocannabinoid administration affects taste preference and the expression of cannabinoid and opioid receptors in the amygdala of early lactating cows.Scientific reports · 2023Article
- Impact of Calorie-Restricted Cafeteria Diet and Treadmill Exercise on Sweet Taste in Diet-Induced Obese Female and Male Rats.Nutrients · 2022Article
- The Influence of Nutritional Status and Sleep Quality on Gustatory Function in Older Adults.Medicina (Kaunas, Lithuania) · 2022Article
- Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms.International journal of molecular sciences · 2022Review
- Article
- Role of Leu72Met ofNutrients · 2022Article
- Intestine-to-neuronal signaling alters risk-taking behaviors in food-deprived Caenorhabditis elegans.PLoS genetics · 2022Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin acts as a potent inhibitory factor against obesity by regulating energy expenditure, food intake, and adiposity. The obese diabetic db/db mouse, which has defects in leptin receptor, displays enhanced neural responses and elevated behavioral preference to sweet stimuli. Here, we show the effects of leptin on the peripheral taste system. An administration of leptin into lean mice suppressed responses of peripheral taste nerves (chorda tympani and glossopharyngeal) to sweet substances (sucrose and saccharin) without affecting responses to sour, salty, and bitter substances. Whole-cell patch-clamp recordings of activities of taste receptor cells isolated from circumvallate papillae (innervated by the glossopharyngeal nerve) demonstrated that leptin activated outward K(+) currents, which resulted in hyperpolarization of taste cells. The db/db mouse with impaired leptin receptors showed no such leptin suppression. Taste tissue (circumvallate papilla) of lean mice expressed leptin-receptor mRNA and some of the taste cells exhibited immunoreactivities to antibodies of the leptin receptor. Taken together, these observations suggest that the taste organ is a peripheral target for leptin, and that leptin may be a sweet-sensing modulator (suppressor) that may take part in regulation of food intake. Defects in this leptin suppression system in db/db mice may lead to their enhanced peripheral neural responses and enhanced behavioral preferences for sweet substances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.