ArticleProceedings of the National Academy of Sciences of the United States of America2000
Influence of follicular dendritic cells on decay of HIV during antiretroviral therapy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 83 citations in OpenAlex.
- Initial viral decay to assess the relative antiretroviral potency of protease inhibitor-sparing, nonnucleoside reverse transcriptase inhibitor-sparing, and nucleoside reverse transcriptase inhibitor-sparing regimens for first-line therapy of HIV infection.AIDS (London, England) · 2011Trial
- Modeling the Interplay Between Viral and Immune Dynamics in HIV: A Review and Mrgsolve Implementation and Exploration.Clinical and translational science · 2025Review
- Impact of Integrase Inhibition Compared With Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Article
- How Germinal Centers Evolve Broadly Neutralizing Antibodies: the Breadth of the Follicular Helper T Cell Response.Journal of virology · 2017Article
- HIV-1 persistent viremia is frequently followed by episodes of low-level viremia.Medical microbiology and immunology · 2017Article
- Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques.JCI insight · 2017Article
- Human systems immunology: hypothesis-based modeling and unbiased data-driven approaches.Seminars in immunology · 2013Review
- Quantification of viral infection dynamics in animal experiments.Frontiers in microbiology · 2013Review
- Modeling the within-host dynamics of HIV infection.BMC biology · 2013Review
- Contribution of follicular dendritic cells to persistent HIV viremia.Journal of virology · 2013Article
- Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age.AIDS (London, England) · 2012Article
- Quantification system for the viral dynamics of a highly pathogenic simian/human immunodeficiency virus based on an in vitro experiment and a mathematical model.Retrovirology · 2012Article
- Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues.PLoS computational biology · 2010Article
- Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences.Journal of virology · 2010Article
- Stage-dependent inhibition of HIV-1 replication by antiretroviral drugs in cell culture.Antimicrobial agents and chemotherapy · 2010Article
- Modeling HIV persistence, the latent reservoir, and viral blips.Journal of theoretical biology · 2009Review
- Compartmentalized human immunodeficiency virus type 1 originates from long-lived cells in some subjects with HIV-1-associated dementia.PLoS pathogens · 2009Article
- Regulation of HIV-1 latency by T-cell activation.Cytokine · 2007Review
- Viral and latent reservoir persistence in HIV-1-infected patients on therapy.PLoS computational biology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
Abstract
Drug treatment of HIV type 1 (HIV-1) infection leads to a rapid initial decay of plasma virus followed by a slower second phase of decay. To investigate the role of HIV-1 retained on follicular dendritic cells (FDCs) in this process, we have developed and analyzed a mathematical model for HIV-1 dynamics in lymphoid tissue (LT) that includes FDCs. Analysis of clinical data using this model indicates that decay of HIV-1 during therapy may be influenced by release of FDC-associated virus. The biphasic character of viral decay can be explained by reversible multivalent binding of HIV-1 to receptors on FDCs, indicating that the second phase of decay is not necessarily caused by long-lived or latently infected cells. Furthermore, viral clearance and death of short-lived productively infected cells may be faster than previously estimated. The model, with reasonable parameter values, is consistent with kinetic measurements of viral RNA in plasma, viral RNA on FDCs, productively infected cells in LT, and CD4(+) T cells in LT during therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.