ArticleThe Journal of cell biology2000
Sustained polymorphonuclear leukocyte transmigration induces apoptosis in T84 intestinal epithelial cells.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Inhibition of MicroRNA-149-5p Induces Apoptosis of Acute Myeloid Leukemia Cell Line THP-1 by Targeting Fas Ligand (FASLG).Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.Microbiology and molecular biology reviews : MMBR · 2013Review
- Promotion of autophagy at the maturation step by IL-6 is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity.Molecular and cellular biochemistry · 2013Article
- The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- The fimbriae of enteroaggregative Escherichia coli induce epithelial inflammation in vitro and in a human intestinal xenograft model.The Journal of infectious diseases · 2012Article
- CD95-mediated cell signaling in cancer: mutations and post-translational modulations.Cellular and molecular life sciences : CMLS · 2012Review
- Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms.Acta pharmacologica Sinica · 2011Article
- Pathobiology of the neutrophil-intestinal epithelial cell interaction: role in carcinogenesis.World journal of gastroenterology · 2010Review
- Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway.American journal of respiratory cell and molecular biology · 2009Article
- Spa15 of Shigella flexneri is secreted through the type III secretion system and prevents staurosporine-induced apoptosis.Infection and immunity · 2009Article
- Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury.American journal of respiratory cell and molecular biology · 2009Review
- Staying alive: bacterial inhibition of apoptosis during infection.Trends in microbiology · 2008Review
- Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease.Journal of gastroenterology · 2007Review
- Involvement of mast cells in gastritis caused by Helicobacter pylori: a potential role in epithelial cell apoptosis.Journal of clinical pathology · 2007Article
- Cellular turnover and expression of hypoxic-inducible factor in acute acalculous and calculous cholecystitis.Critical care (London, England) · 2007Article
- Neutrophils migrate across intestinal epithelium using beta2 integrin (CD11b/CD18)-independent mechanisms.Clinical and experimental immunology · 2004Article
- Afa/Dr diffusely adhering Escherichia coli infection in T84 cell monolayers induces increased neutrophil transepithelial migration, which in turn promotes cytokine-dependent upregulation of decay-accelerating factor (CD55), the receptor for Afa/Dr adhesins.Infection and immunity · 2003Article
- The Afa/Dr adhesins of diffusely adhering Escherichia coli stimulate interleukin-8 secretion, activate mitogen-activated protein kinases, and promote polymorphonuclear transepithelial migration in T84 polarized epithelial cells.Infection and immunity · 2003Article
- Rho GTPase is activated by cytotoxic necrotizing factor 1 in peripheral blood T lymphocytes: potential cytotoxicity for intestinal epithelial cells.Infection and immunity · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute colitis is characterized by a large number of polymorphonuclear leukocytes (PMNLs) migrating across the columnar epithelium in response to inflammatory stimuli. Several of these inflammatory factors have been characterized as proapoptotic inducers for intestinal epithelial cells. Our aim was to elucidate the role of PMNL transmigration in the onset of intestinal epithelial cell apoptosis. We found that PMNL migration, in response to N-formyl-methionyl-leucyl-phenylalanine across monolayers of intestinal epithelial cells (T84), was associated with activation of caspase-2, -3, and -9 and poly(ADP-ribose) polymerase cleavage within epithelial cells. Moreover, dihydrocytochalasin B treatment of T84 cells induced apoptosis with similar characteristics. Although Fas and Fas ligand were expressed on T84 cells and PMNLs, treatment of epithelial cells with an antagonistic anti-Fas antibody failed to prevent apoptosis induced by migrating PMNLs. Owing to the F-actin reorganization accompanying PMNL transmigration, these findings indicate a direct relationship between PMNL migration and induction of apoptosis in epithelial cells. This apoptotic process appears to involve remodeling of the actin cytoskeleton of enterocytes independent of the Fas/Fas ligand pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.