ArticleHeart (British Cardiac Society)2000
Apoptosis in the skeletal muscle of patients with heart failure: investigation of clinical and biochemical changes.
Article in Heart (British Cardiac Society), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 195 citations in OpenAlex.
- PRIME-HF: Novel Exercise for Older Patients with Heart Failure. A Pilot Randomized Controlled Study.Journal of the American Geriatrics Society · 2020Trial
- Levosimendan reduces plasma cell-free DNA levels in patients with ischemic cardiomyopathy.Journal of thrombosis and thrombolysis · 2011Trial
- Exercise Rehabilitation for Heart Failure and Associated Cardiomyopathies.Current cardiology reports · 2025Review
- Effect of optimized new Shengmai powder on exercise tolerance in rats with heart failure by regulating the ubiquitin-proteasome signaling pathway.Frontiers in cardiovascular medicine · 2023Article
- Gut microbiota in sarcopenia and heart failure.The journal of cardiovascular aging · 2022Article
- Contrast-Enhanced Ultrasound of Muscle Perfusion May Indicate Patient Response to Left Ventricular Assist Device Therapy.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021Article
- Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF.ESC heart failure · 2021Article
- Effects of aging and comorbidities on nutritional status and muscle dysfunction in patients with COPD.Journal of thoracic disease · 2018Review
- Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia.Oxidative medicine and cellular longevity · 2018Review
- Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia.Journal of cachexia, sarcopenia and muscle · 2017Article
- Muscle wasting and cachexia in heart failure: mechanisms and therapies.Nature reviews. Cardiology · 2017Review
- Cellular apoptosis in the cardiorenal axis.Heart failure reviews · 2016Review
- Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences.Oxidative medicine and cellular longevity · 2016Review
- The Role of Congestion in Cardiorenal Syndrome Type 2: New Pathophysiological Insights into an Experimental Model of Heart Failure.Cardiorenal medicine · 2015Article
- Skeletal myopathy in patients with chronic heart failure: significance of anabolic-androgenic hormones.Journal of cachexia, sarcopenia and muscle · 2014Article
- Reduced handgrip strength as a marker of frailty predicts clinical outcomes in patients with heart failure undergoing ventricular assist device placement.Journal of cardiac failure · 2014Observational
- Regulation of satellite cell function in sarcopenia.Frontiers in aging neuroscience · 2014Review
- Effects of exercise training on circulating and skeletal muscle renin-angiotensin system in chronic heart failure rats.PloS one · 2014Article
- [Exercise training in heart failure].Herz · 2013Article
- Demographics and clinical and economic characteristics of patients receiving total hip arthroplasty with and without muscle atrophy/weakness.ClinicoEconomics and outcomes research : CEOR · 2013Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the contribution of apoptosis in the development of the skeletal myopathy in chronic heart failure.
designThe electrophoretic pattern of myosin heavy chains (MHC), fibre cross sectional area, number of in situ nick end labelling (TUNEL) positive apoptotic myocyte nuclei, and the tissue levels of caspase-3, Bcl-2, and ubiquitin were determined in biopsies taken from the vastus lateralis muscle. The study involved nine patients with severe chronic heart failure caused by ischaemic heart disease and hibernating myocardium and five controls.
resultsIn chronic heart failure patients the vastus lateralis showed a significant increase of MHC(2a) and MHC(2b) and a greater degree of fibre atrophy, as demonstrated by the decreased cross sectional area. There was also an increased number of TUNEL positive apoptotic myocyte nuclei. Tissue concentrations of Bcl-2 were decreased, while those of caspase-3 and ubiquitin were increased. Peak oxygen consumption (VO(2)) was negatively correlated with the number of TUNEL positive nuclei and the fibre cross sectional area. There was a correlation between the number of apoptotic nuclei and the fibre cross sectional area, but no correlation between myosin heavy chains and number of apoptotic nuclei.
conclusionsMyocyte apoptosis occurs in the skeletal muscle of patients with chronic heart failure, and its magnitude is associated with the severity of exercise capacity limitation and the degree of muscle atrophy. Muscle atrophy contributes to the limitation of exercise capacity, together with the increased synthesis of fast, more fatiguable myosin heavy chains.
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