ArticleThe Journal of experimental medicine2000
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer.Advances in experimental medicine and biology · 2024Article
- Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics.Scientific reports · 2016Article
- SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.The Journal of biological chemistry · 2013Article
- Mast cell chemotaxis - chemoattractants and signaling pathways.Frontiers in immunology · 2012Article
- The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.The EMBO journal · 2011Article
- Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.The EMBO journal · 2011Article
- Transmembrane adaptor proteins in the high-affinity IgE receptor signaling.Frontiers in immunology · 2011Article
- Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.Advances in immunology · 2011Review
- Itk: the rheostat of the T cell response.Journal of signal transduction · 2011Article
- Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.Journal of thrombosis and haemostasis : JTH · 2008Article
- Dual role of the adaptor protein SLP-65: organizer of signal transduction and tumor suppressor of pre-B cell leukemia.Immunologic research · 2006Review
- Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.Immunology · 2004Article
- Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.The EMBO journal · 2004Article
- Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.The Biochemical journal · 2003Article
- Positive and negative regulation of T-cell activation through kinases and phosphatases.The Biochemical journal · 2003Review
- Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells.Molecular and cellular biology · 2003Article
- Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes.The Journal of experimental medicine · 2002Article
- Adapters in lymphocyte signaling.The Journal of clinical investigation · 2002Review
- Differential role of SLP-76 domains in T cell development and function.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation.The Journal of experimental medicine · 2002Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
B cell linker protein (BLNK) and Src homology 2 domain-containing leukocyte protein of 76 kD (SLP-76) are adaptor proteins required for B cell receptor (BCR) and T cell receptor function, respectively. Here, we show that expression of SLP-76 cannot reconstitute BCR function in Zap-70(+)BLNK(-) B cells. This could be attributable to inability of SLP-76 to be recruited into glycolipid-enriched microdomains (GEMs) after antigen receptor cross-linking. Supporting this idea, the BCR function was restored when a membrane-associated SLP-76 chimera was enforcedly localized to GEMs. Moreover, we demonstrate that addition of both linker for activation of T cells (LAT) and Grb2-related adaptor downstream of Shc (Gads) to SLP-76 allow SLP-76 to be recruited into GEMs, whereby the BCR function is reconstituted. The Gads function was able to be replaced by overexpression of Grb2. In contrast to SLP-76, BLNK did not require Grb2 families for its recruitment to GEMs. Hence, these data suggest a functional overlap between BLNK and SLP-76, while emphasizing the difference in requirement for additional adaptor molecules in their targeting to GEMs.
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