ArticleThe Journal of experimental medicine2000
The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 80 citations in OpenAlex.
- p66Shc in Cardiovascular Pathology.Cells · 2022Review
- The mitochondrial PKCδ/retinol signal complex exerts real-time control on energy homeostasis.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- Manipulation of retinoic acid signaling in the nucleus accumbens shell alters rat emotional behavior.Behavioural brain research · 2019Article
- Retinol as electron carrier in redox signaling, a new frontier in vitamin A research.Hepatobiliary surgery and nutrition · 2016Review
- Vitamin A/retinol and maintenance of pluripotency of stem cells.Nutrients · 2014Review
- Nitric oxide and zinc-mediated protein assemblies involved in mu opioid receptor signaling.Molecular neurobiology · 2013Review
- Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα.The Biochemical journal · 2012Article
- In vitro optimization of retinoic acid-induced neuritogenesis and TH endogenous expression in human SH-SY5Y neuroblastoma cells by the antioxidant Trolox.Molecular and cellular biochemistry · 2011Article
- Are zinc-finger domains of protein kinase C dynamic structures that unfold by lipid or redox activation?Antioxidants & redox signaling · 2011Article
- Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells.Molecular biology of the cell · 2006Article
- Retinoylserine and retinoylalanine, natural products of the moth Trichoplusia ni.Journal of natural products · 2005Article
- Retinoid targets for apoptosis induction.Oncogene · 2003Review
- Evolution, biochemistry and genetics of protein kinase C in fungi.Current genetics · 2003Review
- Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling.The Journal of clinical investigation · 2003Review
- Protein kinase Cepsilon actin-binding site is important for neurite outgrowth during neuronal differentiation.Molecular biology of the cell · 2002Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Vitamin A and its biologically active derivatives, the retinoids, are recognized as key regulators of vertebrate development, cell growth, and differentiation. Although nuclear receptors have held the attention since their discovery a decade ago, we report here on serine/threonine kinases as a new class of retinoid receptors. The conserved cysteine-rich domain of the NH(2)-terminal regulatory domains of cRaf-1, as well as several select domains of the mammalian protein kinase C (PKC) isoforms alpha, delta, zeta, and mu, the Drosophila and yeast PKCs, were found to bind retinol with nanomolar affinity. The biological significance was revealed in the alternate redox activation pathway of these kinases. Retinol served as a cofactor to augment the activation of both cRaf and PKC alpha by reactive oxygen, whereas the classical receptor-mediated pathway was unaffected by the presence or absence of retinol. We propose that bound retinol, owing to its electron transfer capacity, functions as a tag to enable the efficient and directed redox activation of the cRaf and PKC families of kinases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.