ArticleInfection and immunity2000
Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2004Trial
- Article
- Foundational concepts in the biology of bacterial keratitis.Experimental eye research · 2021Review
- Comparative genomic analysis of a naturally competent Elizabethkingia anophelis isolated from an eye infection.Scientific reports · 2018Article
- The Pathogenesis of Staphylococcus aureus Eye Infections.Pathogens (Basel, Switzerland) · 2018Review
- 2-O-Sulfated Domains in Syndecan-1 Heparan Sulfate Inhibit Neutrophil Cathelicidin and Promote Staphylococcus aureus Corneal Infection.The Journal of biological chemistry · 2015Article
- Evaluation of genetically inactivated alpha toxin for protection in multiple mouse models of Staphylococcus aureus infection.PloS one · 2013Article
- CD4 T cell antigens from Staphylococcus aureus Newman strain identified following immunization with heat-killed bacteria.Clinical and vaccine immunology : CVI · 2012Article
- Active Immunization with Pneumolysin versus 23-Valent Polysaccharide Vaccine for Streptococcus pneumoniae Keratitis.Investigative ophthalmology & visual science · 2011Article
- Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence.Future microbiology · 2011Review
- Syndecan-1 promotes Staphylococcus aureus corneal infection by counteracting neutrophil-mediated host defense.The Journal of biological chemistry · 2011Article
- Animal models of bacterial keratitis.Journal of biomedicine & biotechnology · 2011Review
- Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase.PloS one · 2010Article
- Serologic assay to quantify human immunoglobulin G antibodies to the Staphylococcus aureus iron surface determinant B antigen.Clinical and vaccine immunology : CVI · 2009Article
- Protection from Streptococcus pneumoniae keratitis by passive immunization with pneumolysin antiserum.Investigative ophthalmology & visual science · 2008Article
- Immunization with polyamine transport protein PotD protects mice against systemic infection with Streptococcus pneumoniae.Infection and immunity · 2006Article
- Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine.Infection and immunity · 2005Article
- Corneal ulceration in pediatric patients: a brief overview of progress in topical treatment.Paediatric drugs · 2002Review
- Non-antibiotic management of bacterial keratitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toxoid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.