ArticleInfection and immunity2000
Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- The abundance and morphology of human large intestinal goblet and tuft cells during chronic schistosomiasis.Parasite immunology · 2023Article
- Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections.Parasite immunology · 2021Review
- Immunomodulatory dynamics of excretory and secretory products on Th9 immune response during Haemonchus contortus infection in goat.PLoS neglected tropical diseases · 2020Article
- Galectin Domain Containing Protein fromBiomolecules · 2020Article
- Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver.Scientific reports · 2017Article
- IL-9 and Th9 in parasite immunity.Seminars in immunopathology · 2017Review
- Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200a/Beta-Catenin Axis.BioMed research international · 2017Article
- Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages.Immunology · 2016Review
- Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.Nature communications · 2016Article
- IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.The Journal of experimental medicine · 2013Article
- Article
- The many lives of IL-9: a question of survival?Nature immunology · 2012Article
- Schistosoma mansoni antigen Sm-p80: Prophylactic efficacy of a vaccine formulated in human approved plasmid vector and adjuvant (VR 1020 and alum).Acta tropica · 2011Article
- Pathway analysis comparison using Crohn's disease genome wide association studies.BMC medical genomics · 2010Article
- Th9 and allergic disease.Immunology · 2009Review
- IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections.BMC immunology · 2008Article
- IL-9 promotes anti-Mycobacterium leprae cytotoxicity: involvement of IFNgamma.Clinical and experimental immunology · 2007Article
- A case of bowel schistosomiasis not adhering to endoscopic findings.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Mice infected with Schistosoma mansoni develop Th2 cytokine-mediated granulomatous pathology that is focused on the liver and intestines. In this study, transgenic mice constitutively expressing IL-9 were infected with S. mansoni and the outcome of infection was determined. Eight weeks after infection, transgenic mice with acute infections had a moderate increase in Th2 cytokine production but were overtly normal with respect to parasite infection and pathological responses. Transgenic mice with chronic infections died 10 weeks after infection, with 86% of transgenic mice dead by week 12 of infection, compared to 7% mortality in infected wild-type mice. Stimulation of mesenteric lymph node cells from infected transgenic mice with parasite antigen elicited elevated interleukin-4 (IL-4) and IL-5 production and reduced gamma interferon and tumor necrosis factor alpha production compared to the responses in wild-type mice. Morbid transgenic mice had substantial enlargement of the ileum, which was associated with muscular hypertrophy, mastocytosis, eosinophilia, goblet cell hyperplasia, and increased mucin expression. We also observed that uninfected transgenic mice exhibited alterations in their intestines. Although there was hepatic mastocytosis and eosinophilia in infected transgenic mice, there was no hepatocyte damage. Death of transgenic mice expressing IL-9 during schistosome infection was primarily associated with enteropathy. This study highlights the pleiotropic in vivo activity of IL-9 and demonstrates that an elevated Th2 cytokine phenotype leads to death during murine schistosome infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.